中文名 | 异鼠李素 |
英文名 | Isorhamnetin |
别名 | 异鼠李素 异鼠李素(标准品) 异鼠李素, 来源于沙棘 异鼠李素ISORHAMNETIN ISORHAMNETIN 异鼠李素 3,5,7-三羟基-2-(4-羟基-3-甲氧基苯基)苯并吡喃-4-酮 异鼠李素(3,5,7-三羟基-2-(4-羟基-3-甲氧基苯基)苯并吡喃-4-酮) |
英文别名 | C.I. 75680 Isohamnetin Isorhamnetin 3-Methylquercetin 3'-METHOXY-3,5,7,4'-TETRAHYDROXYFLAVONE 3'-METHOXY-3,4',5,7-TETRAHYDROXYFLAVONE IsorhaMnetin, froM Hippophae fhaMnoides L. 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-one 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)- sorhamnetin 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on |
CAS | 480-19-3 |
EINECS | 207-545-5 |
化学式 | C16H12O7 |
分子量 | 316.26 |
InChI | InChI=1/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3 |
InChIKey | IZQSVPBOUDKVDZ-UHFFFAOYSA-N |
密度 | 1.634±0.06 g/cm3(Predicted) |
熔点 | 307°C |
沸点 | 599.4±50.0 °C(Predicted) |
闪点 | 227.8°C |
蒸汽压 | 5.79E-15mmHg at 25°C |
溶解度 | 微溶于水、甲醇,可溶于甲醇和氯仿的混合溶剂,易溶于DMSO。 |
折射率 | 1.74 |
酸度系数 | 6.31±0.40(Predicted) |
存储条件 | 2-8°C |
外观 | 整洁 |
颜色 | Light yellow to Amber to Dark green |
BRN | 44723 |
MDL号 | MFCD00017310 |
体外研究 | Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC 50 , ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC 50 , 38 µM). |
体内研究 | Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm 3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm 3 , respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group. |
危险品标志 | Xi - 刺激性物品 Xn - 有害物品 |
风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R40 - 少数报道有致癌后果。 |
安全术语 | S22 - 切勿吸入粉尘。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36/37 - 穿戴适当的防护服和手套。 |
WGK Germany | 3 |
RTECS | LK9275450 |
海关编号 | 29329990 |
上游原料 | 香兰素 |
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