异鼠李素ISORHAMNETIN
异鼠李素(Isorhamnetin)
CAS: 480-19-3
化学式: C16H12O7
| 中文名 | 异鼠李素 |
| 英文名 | Isorhamnetin |
| 别名 | 异鼠李素 异鼠李素(标准品) 异鼠李素, 来源于沙棘 异鼠李素ISORHAMNETIN ISORHAMNETIN 异鼠李素 3,5,7-三羟基-2-(4-羟基-3-甲氧基苯基)苯并吡喃-4-酮 异鼠李素(3,5,7-三羟基-2-(4-羟基-3-甲氧基苯基)苯并吡喃-4-酮) |
| 英文别名 | C.I. 75680 Isohamnetin Isorhamnetin 3-Methylquercetin 3'-METHOXY-3,5,7,4'-TETRAHYDROXYFLAVONE 3'-METHOXY-3,4',5,7-TETRAHYDROXYFLAVONE IsorhaMnetin, froM Hippophae fhaMnoides L. 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-one 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)- sorhamnetin 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on |
| CAS | 480-19-3 |
| EINECS | 207-545-5 |
| 化学式 | C16H12O7 |
| 分子量 | 316.26 |
| InChI | InChI=1/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3 |
| InChIKey | IZQSVPBOUDKVDZ-UHFFFAOYSA-N |
| 密度 | 1.634±0.06 g/cm3(Predicted) |
| 熔点 | 307°C |
| 沸点 | 599.4±50.0 °C(Predicted) |
| 闪点 | 227.8°C |
| 蒸汽压 | 5.79E-15mmHg at 25°C |
| 溶解度 | 微溶于水、甲醇，可溶于甲醇和氯仿的混合溶剂，易溶于DMSO。 |
| 折射率 | 1.74 |
| 酸度系数 | 6.31±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 整洁 |
| 颜色 | Light yellow to Amber to Dark green |
| BRN | 44723 |
| MDL号 | MFCD00017310 |
| 体外研究 | Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC 50 , ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC 50 , 38 µM). |
| 体内研究 | Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm 3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm 3 , respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group. |
| 危险品标志 | Xi - 刺激性物品 Xn - 有害物品  |
| 风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R40 - 少数报道有致癌后果。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36/37 - 穿戴适当的防护服和手套。 |
| WGK Germany | 3 |
| RTECS | LK9275450 |
| 海关编号 | 29329990 |
| 上游原料 | 1-(2-羟基-4,6-双(甲氧基甲氧基)苯基)乙酮 |
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异鼠李素ISORHAMNETIN - 简介
异鼠李素，化学名为4-氨基-2,2-二甲基-3-(1H-咪唑-4-基)戊酮，是一种有机化合物。以下是关于异鼠李素的性质、用途、制法和安全信息的介绍：
性质：
异鼠李素是无色结晶性固体，在常温下易溶于水和有机溶剂。它具有咪唑环和酮基的结构，是一种具有独特分子构型的化合物。
用途：
异鼠李素在药学领域被广泛应用。异鼠李素还可用作化学试剂，特别是在合成有机化合物的过程中。
制法：
异鼠李素的制备方法较为复杂，通常通过化学合成获得。制备方法涉及多步反应，主要是通过适当原料的反应和纯化过程来得到目标产物。
安全信息：
异鼠李素在使用过程中需注意以下安全信息：
应避免直接接触皮肤和眼睛，避免吸入气溶胶。
在操作和储存时，应加强防护措施，穿戴化学防护服和护目镜，并确保操作在通风良好的地方进行。
如意外摄入或吸入，应立即就医，并带上相关化合物的标签或其安全数据表。
性质：
异鼠李素是无色结晶性固体，在常温下易溶于水和有机溶剂。它具有咪唑环和酮基的结构，是一种具有独特分子构型的化合物。
用途：
异鼠李素在药学领域被广泛应用。异鼠李素还可用作化学试剂，特别是在合成有机化合物的过程中。
制法：
异鼠李素的制备方法较为复杂，通常通过化学合成获得。制备方法涉及多步反应，主要是通过适当原料的反应和纯化过程来得到目标产物。
安全信息：
异鼠李素在使用过程中需注意以下安全信息：
应避免直接接触皮肤和眼睛，避免吸入气溶胶。
在操作和储存时，应加强防护措施，穿戴化学防护服和护目镜，并确保操作在通风良好的地方进行。
如意外摄入或吸入，应立即就医，并带上相关化合物的标签或其安全数据表。
最后更新：2024-04-09 20:52:54
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产品名: 异鼠李素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: II04101
产地: 北京
包装: 1ml/瓶
规格: II04101-1ml
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提供多种规格现货供应
产品名: 异鼠李素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: II04101
产地: 北京
包装: 1ml/瓶
规格: II04101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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