5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺盐酸盐
利莫那班盐酸盐(Rimonabant hydrochloride)
CAS: 158681-13-1
化学式: C22H21Cl3N4O.ClH
| 中文名 | 利莫那班盐酸盐 |
| 英文名 | Rimonabant hydrochloride |
| 别名 | 利莫那般 盐酸利莫那班 利莫那班盐酸盐 利莫那班D10盐酸 盐酸利莫那班[干冰运输] 5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺盐酸盐 N-(哌啶-1-基)-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-甲酰胺盐酸盐 5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺单盐酸盐 |
| 英文别名 | ACOMPLIA Rimonabant HCl RIMONABANT HCL Rimonabant hcl Acomplia, SR141716 Rimonabant(Acomplia) ACOMPLIA (RIMONABANT RIMONABANT HYDROCHLORIDE Rimonabant hydrochloride RimonabantConsultedStandard N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide monohydrochloride 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, monohydrochloride |
| CAS | 158681-13-1 |
| EINECS | 233-720-0 |
| 化学式 | C22H21Cl3N4O.ClH |
| 分子量 | 500.25 |
| InChI | InChI=1/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H |
| 熔点 | 230-240°C |
| 沸点 | 627.6℃ at 760 mmHg |
| 溶解度 | DMSO: 可溶20mg/mL，澄清 |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| 体外研究 | Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant. Rimonabant itself (10 -12 -10 -3 M, 12 concentrations) inhibits the basal binding of [ 35 S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC 50 of 4.7±0.2 (IC 50 = 20 μM) and a maximal inhibition of 48±2%. |
| 体内研究 | Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant . Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors. |
| 危险品标志 | T - 有毒物品 Xi - 刺激性物品  |
| 风险术语 | R25 - 吞食有毒。 R36 - 刺激眼睛。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| 上游原料 | 叔丁醇钾 1-氨基哌啶 4-氯苯丙酮 2,4-二氯苯肼盐酸盐 |
供应商列表
现货供应
产品名: Rimonabant Hydrochloride 去供应商网站查看 询盘CAS: 158681-13-1
产地: 上海
规格: R881908
价格: 10mg-444,50mg-1602
库存: 现货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
提供多种规格现货供应
产品名: Rimonabant hydrochloride 去供应商网站查看 询盘CAS: 158681-13-1
产地: 上海
规格: HPLC≥98%
价格: 10mg 400
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Rimonabant hydrochloride HPLC≥98% 源叶 货号：B27940
现货供应
产品名: Rimonabant Hydrochloride 去供应商网站查看 询盘CAS: 158681-13-1
产地: 上海
规格: R881908
价格: 10mg-444,50mg-1602
库存: 现货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
提供多种规格现货供应
产品名: Rimonabant hydrochloride 去供应商网站查看 询盘CAS: 158681-13-1
产地: 上海
规格: HPLC≥98%
价格: 10mg 400
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Rimonabant hydrochloride HPLC≥98% 源叶 货号：B27940
5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺盐酸盐的上游原料
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