利莫那班D10盐酸

中文名	利莫那班盐酸盐
英文名	Rimonabant hydrochloride
别名	利莫那般盐酸利莫那班利莫那班盐酸盐利莫那班D10盐酸盐酸利莫那班[干冰运输] 5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺盐酸盐 N-(哌啶-1-基)-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-甲酰胺盐酸盐 5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(1-哌啶基)-1H-吡唑-3-甲酰胺单盐酸盐
英文别名	ACOMPLIA Rimonabant HCl RIMONABANT HCL Rimonabant hcl Acomplia, SR141716 Rimonabant(Acomplia) ACOMPLIA (RIMONABANT RIMONABANT HYDROCHLORIDE Rimonabant hydrochloride RimonabantConsultedStandard N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide monohydrochloride 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, monohydrochloride
CAS	158681-13-1
EINECS	233-720-0
化学式	C22H21Cl3N4O.ClH
分子量	500.25
InChI	InChI=1/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H
熔点	230-240°C
沸点	627.6℃ at 760 mmHg
溶解度	DMSO: 可溶20mg/mL，澄清
存储条件	2-8°C
外观	粉末
颜色	white to beige
体外研究	Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant. Rimonabant itself (10 -12 -10 -3 M, 12 concentrations) inhibits the basal binding of [ 35 S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC 50 of 4.7±0.2 (IC 50 = 20 μM) and a maximal inhibition of 48±2%.
体内研究	Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant . Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors.
危险品标志	T - 有毒物品 Xi - 刺激性物品
风险术语	R25 - 吞食有毒。 R36 - 刺激眼睛。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
危险品运输编号	UN 2811 6.1 / PGIII
WGK Germany	3
上游原料	草酸二乙酯叔丁醇钾 1-氨基哌啶

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CAS: 158681-13-1
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包装: 5mg/瓶;
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产品名: 利莫那班盐酸盐去供应商网站查看询盘
CAS: 158681-13-1
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包装: 10mg
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产品名: Rimonabant Hydrochloride 去供应商网站查看询盘
CAS: 158681-13-1
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产品名: Rimonabant hydrochloride 去供应商网站查看询盘
CAS: 158681-13-1
产地: 上海
规格: HPLC≥98%
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