中文名 | 谷胱甘肽 |
英文名 | Glutathione |
别名 | 谷胱甘肽 谷光甘肽 L-谷胱甘肽 L-谷胱苷肽 还原型谷胱苷肽 还原型谷胱甘肽 谷胱甘肽(GSH) 谷胱甘肽(还原型) 谷胱甘肽(GSSG) 谷胱甘肽(还原性谷胱甘肽) Γ-谷氨酰-半胱氨酰-甘氨酸 5-L-谷氨酰-L-半胱氨酰甘氨酸 GLUTATHIONE REDUCED 还原型谷胱甘肽 |
英文别名 | GSH glutide glutinal isethion glutatiol glutatione Glutathion Glutathione l-glutatione L-Glutathione ReducedGlutathione Antisense compounds Glutathione reduced Glutathione, reduced gamma-glutamylcysteinylglycine 5-l-glutamyl-l-cysteinylglycine Glutathione, Reduced, Free Acid gamma-L-Glutamyl-L-cysteinylglycine L-gamma-glutamyl-L-cysteinylglycine n-(n-l-gamma-glutamyl-l-cysteinyl)-glycin L-gamma-glutamyl-3-sulfido-L-alanylglycine N(N-L-.gamma.-Glutamyl-L-cysteinyl)glycine {[N-(2-ammonio-4-carboxybutanoyl)cysteinyl]amino}acetate |
CAS | 70-18-8 |
EINECS | 200-725-4 |
化学式 | C10H17N3O6S |
分子量 | 307.32 |
InChI | InChI=1/C10H17N3O6S/c11-5(1-2-7(14)15)9(18)13-6(4-20)10(19)12-3-8(16)17/h5-6,20H,1-4,11H2,(H,12,19)(H,13,18)(H,14,15)(H,16,17) |
InChIKey | RWSXRVCMGQZWBV-WDSKDSINSA-N |
密度 | 1.4482 (rough estimate) |
熔点 | 192-195 °C (dec.) (lit.) |
沸点 | 754.5±60.0 °C(Predicted) |
比旋光度 | -16.5 º (c=2, H2O) |
闪点 | 411.272°C |
水溶性 | soluble |
蒸汽压 | 0mmHg at 25°C |
溶解度 | H2O: 50 mg/mL |
折射率 | -17 ° (C=2, H2O) |
酸度系数 | pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃) |
PH值 | 3 (10g/l, H2O, 20°C) |
存储条件 | 2-8°C |
稳定性 | 稳定。与强氧化剂不相容。 |
敏感性 | Sensitive to air |
外观 | 粉末 |
颜色 | White |
气味 | Odorless |
Merck | 14,4475 |
BRN | 1729812 |
物化性质 | 谷胱甘肽的分子量为307.33,熔点189~193℃ (分解),晶体呈无色透明细长柱状,等电点为5.93。它溶于水、稀醇、液氨和甲基甲酰胺,而不溶于醇、醚和丙酮。生物体内只有GSH才具有生理活性,而GSSG需还原后才能发挥其重要的生理功能。GSH在高水分活性下不易保存,只有将水分活性控制在0.3以下才能够长期稳定保存。有研究显示,在含有GSH的维生素C水溶液(pH3.3)中,由于有维生素C的强还原作用,溶液中的GSH不会氧化为GSSG,但其分解速度却加快;而存在于维生素C水溶液中的GSSG也不会转变为GSH,且保存稳定性很好。并且经口摄入的GSSG在小肠上部可被还原为GSH,在小肠上皮细胞表面经γ-GTP(将GSH分解为谷氨酸与Cys-Gly)及二肽酶的作用而被吸收,同样可以发挥其重要的生理功能。 谷胱甘肽广泛存在于动、植物中,在面包酵母、小麦胚芽和动物肝脏中的含量极高,达100~1000mg/100g;在人和动物的血液中含量也较丰富,如人血液中含26~34mg/100g、鸡血中含58~73mg/100g、猪血中含10~15mg/100g、狗血中含14~22mg/100g。许多蔬菜、薯类和谷物中也含有GSH (见表1)。 以上信息由彤彤编辑整理。 |
MDL号 | MFCD00065939 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | R68 - 可能有不可逆后果的危险。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S27 - 一旦衣物受到污染,请立即脱去。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 2 |
RTECS | MC0556000 |
FLUKA BRAND F CODES | 9-23 |
TSCA | Yes |
海关编号 | 29309070 |
上游原料 | 酵母 II 硫化氢 |
下游产品 | 前列腺素E1 地诺前列酮 4,4'-二羧基二苯二硫醚 |
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