中文名 | 亚叶酸 |
英文名 | 5-formyltetrahydrofolic acid |
别名 | 亚叶酸 菊白葉酸 5-甲酰四氢叶酸 5-甲酰-5,6,7,8-四氢叶酸 5-甲醯-5,6,7,8-四氫葉酸 |
英文别名 | leucoverin Folinic Acid 5-formyltetrahydrofolate N5-formyl-tetrahydrofolate 5-formyltetrahydrofolic acid 5-formyl-5,6,7,8-tetrahydrofolate N5-formyl-5,6,7,8-tetrahydrofolate 5-formyl-5,6,7,8-tetrahydropteroyl-l-glutamicacid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid 2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid |
CAS | 58-05-9 |
EINECS | 200-361-6 |
化学式 | C20H23N7O7 |
分子量 | 473.44 |
InChI | InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1 |
密度 | 1.4485 (rough estimate) |
熔点 | 245°C (rough estimate) |
沸点 | 573.92°C (rough estimate) |
比旋光度 | D20 +14.26° (c = 3.42 as anhydr Ca salt) |
水溶性 | >1350g/L(25 ºC) |
折射率 | 1.6800 (estimate) |
酸度系数 | 3.1, 4.8, 10.4(at 25℃) |
存储条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
体外研究 | MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) . |
上游原料 | 二乙氨基乙醇 |
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