中文名 | 6-氨基屈 |
英文名 | 6-Aminochrysene |
别名 | 6-氨基屈 化合物 T13519 7-胺基去乙酰氧基头胞烷酸 |
英文别名 | ADCA 6-Amc Chrysenex Chrysonex AMINOCHRYSENE 6-CHRYSENAMINE 6-Chrysenamine 6-Aminochrysene 6-AMINOCHRYSENE chrysen-6-amine chrysen-6-ylamine AMINOCHRYSENE, 6- |
CAS | 2642-98-0 |
EINECS | 220-149-7 |
化学式 | C18H13N |
分子量 | 243.3 |
InChI | InChI=1/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2 |
密度 | 0.8933 (rough estimate) |
熔点 | 209-211°C(lit.) |
沸点 | 376.18°C (rough estimate) |
闪点 | 286.9°C |
水溶性 | 155ug/L(24 ºC) |
蒸汽压 | 3.56E-10mmHg at 25°C |
溶解度 | 丙酮 (微溶),氯仿 (微溶),甲醇 (微溶,加热) |
折射率 | 1.4500 (estimate) |
酸度系数 | 4.32±0.30(Predicted) |
存储条件 | 2-8°C |
外观 | 固体 |
颜色 | Yellow to Brown |
Merck | 13,2275 |
体外研究 | 6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation. |
体内研究 | 6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration. |
危险品标志 | Xn - 有害物品 |
风险术语 | 22 - 吞食有害。 |
安全术语 | S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | GC0500000 |
海关编号 | 29214900 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.11 ml | 20.551 ml | 41.102 ml |
5 mM | 0.822 ml | 4.11 ml | 8.22 ml |
10 mM | 0.411 ml | 2.055 ml | 4.11 ml |
5 mM | 0.082 ml | 0.411 ml | 0.822 ml |
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