中文名 | JW-55 |
英文名 | JW-55 |
别名 | Β-CATENIN抑制剂(JW 55) N-(4-(((4-(4-甲氧基苯基)四氢-2H-吡喃-4-基)甲基)氨甲酰)苯基)呋喃-2-甲酰胺 N-(4-((4-(4-甲氧基苯基)四氢-2H-吡喃-4-基)甲基氨基甲酰基)苯基)呋喃-2-甲酰胺 N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺 N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺(JW55) |
英文别名 | JW55 JW-55 N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide |
CAS | 664993-53-7 |
化学式 | C25H26N2O5 |
分子量 | 434.48 |
密度 | 1.235±0.06 g/cm3(Predicted) |
沸点 | 572.6±50.0 °C(Predicted) |
溶解度 | DMSO: 可溶15mg/mL,澄清 |
酸度系数 | 12.41±0.70(Predicted) |
存储条件 | Inert atmosphere,2-8°C |
外观 | 粉末 |
颜色 | white to beige |
体外研究 | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. |
体内研究 | JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice. |
WGK Germany | 3 |
参考资料 展开查看 | 1. [IF=5.914] Jing Xie et al."Short-chain fatty acids produced by Ruminococcaceae mediates α-Linolenic acid promote intestinal stem cells proliferation."Molecular Nutrition & Food Research. 2021 Oct 28 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.302 ml | 11.508 ml | 23.016 ml |
5 mM | 0.46 ml | 2.302 ml | 4.603 ml |
10 mM | 0.23 ml | 1.151 ml | 2.302 ml |
5 mM | 0.046 ml | 0.23 ml | 0.46 ml |
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