69304-47-8
溴夫定(Brivudine)
CAS: 69304-47-8
化学式: C11H13BrN2O5
| 中文名 | 溴夫定 |
| 英文名 | Brivudine |
| 别名 | 溴夫啶 溴呋啶 溴夫定 溴乙烯尿苷 溴夫定(标准品) (E)-5-(2-溴乙烯基)-2'-脱氧核苷 5-(E)-(2-溴乙烯基)-2'-脱氧尿苷 5-[(E)-2-溴乙烯基]-1-[(2R,4S,5R)-4-羟基-5-(羟甲基)氧杂环戊-2-基]嘧啶-2,4-二酮 |
| 英文别名 | BVDU Helpin BRIVUDINE Brivudine (E)-(5)-BROMOVINYL-2-DEOXYURIDINE E-5-(2-Bromovinyl)-2'-Deoxy-Uridine 5-(E)-(2-Bromovinyl)-2-deoxyuridine (E)-5-(2-bromovinyl)-2'-deoxyuridine (E)-5-(2-Bromovinyl)-2'-deoxyuridine (E)-5-(2-BROMOVINYL)-2'-DEOXY-URIDINE 5-[(E)-2-bromoethenyl]-2'-deoxyuridine Uridine,5-[(1E)-2-broMoethenyl]-2'-deoxy- 5-[(E)-2-bromoethenyl]-1-(2-deoxy-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione N-(2,6-dichloro-4-{[(2-chloroethyl)(methyl)amino]methyl}phenyl)-4,5-dihydro-1H-imidazol-2-amine dihydrochloride |
| CAS | 69304-47-8 |
| EINECS | 1806241-263-5 |
| 化学式 | C11H13BrN2O5 |
| 分子量 | 333.14 |
| InChI | InChI=1/C13H17Cl3N4.2ClH/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13;;/h6-7H,2-5,8H2,1H3,(H2,17,18,19);2*1H |
| InChIKey | ODZBBRURCPAEIQ-CXYVBZRVSA-N |
| 密度 | 1.7800 (rough estimate) |
| 熔点 | 165°C |
| 沸点 | 382.9°C at 760 mmHg |
| 闪点 | 185.4°C |
| 水溶性 | Soluble in water and methanol. |
| 蒸汽压 | 4.56E-06mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.6520 (estimate) |
| 酸度系数 | 8.37±0.10(Predicted) |
| 存储条件 | Inert atmosphere,2-8°C |
| 外观 | 固体 |
| 颜色 | Off-White |
| Merck | 14,1378 |
| MDL号 | MFCD00058585 |
| 体外研究 | Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage. |
| 体内研究 | At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia. |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | YU7355000 |
| 海关编号 | 29349990 |
69304-47-8 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.002 ml | 15.009 ml | 30.017 ml |
| 5 mM | 0.6 ml | 3.002 ml | 6.003 ml |
| 10 mM | 0.3 ml | 1.501 ml | 3.002 ml |
| 5 mM | 0.06 ml | 0.3 ml | 0.6 ml |
最后更新：2024-01-02 23:10:35
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产品名: 5-((E)-2-溴乙烯基)-1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮 去供应商网站查看 询盘CAS: 69304-47-8
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提供多种规格现货供应
产品名: 5-((E)-2-溴乙烯基)-1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮 去供应商网站查看 询盘CAS: 69304-47-8
产地: 北京
包装: 瓶
规格: YS103973-100mg,YS103973-1g,YS103973-250mg,YS103973-5g
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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