中文名 | (R)-巴氯芬 |
英文名 | (R)-baclofen |
别名 | -巴氯芬 (R)-巴氯芬 (R)-4-氨基-3-(4-氯苯基)丁酸 (R)-3-(4-氯苯基)-4-氨基丁酸 |
英文别名 | STX 209 l-Baclofen D-Baclofen (R)-baclofen (R)-Baclofen (-)-Baclofen R-(-)-Baclofen UNII-NYU6UTW25B (R)-(-)-Baclofen 4-azanyl-3-(4-chlorophenyl)butanoic acid (R)-4-Amino-3-(4-chlorophenyl)butyric acid (R)-4-Amino-3-(4-chlorophenyl)butanoic acid (3R)-4-amino-3-(4-chlorophenyl)butanoic acid (βR)-β-(AMinoMethyl)-4-chlorobenzenepropanoic Acid Benzenepropanoic acid, b-(aMinoMethyl)-4-chloro-, (bR)- Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)- Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, (R)- Benzeneporopanoic acid, (beta-(aminomethyl)-4-chloro-, (betaR)- |
CAS | 69308-37-8 |
化学式 | C10H12ClNO2 |
分子量 | 213.66 |
InChI | InChI=1/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1 |
密度 | 1.285±0.06 g/cm3(Predicted) |
熔点 | 171-174°C |
沸点 | 364.3±32.0 °C(Predicted) |
闪点 | 174.1°C |
蒸汽压 | 6.01E-06mmHg at 25°C |
折射率 | 1.576 |
酸度系数 | 4.04±0.10(Predicted) |
存储条件 | Keep in dark place,Inert atmosphere,Room temperature |
体内研究 | (R)-Baclofen (STX209) suppresses audiogenic seizures in the Fmr1 -knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg . Acute intraperitoneal administration of (R)-Baclofen (STX209) significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg. |
危险品运输编号 | 2811 |
RTECS | DA8339450 |
Hazard Class | 6.1 |
Packing Group | III |
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