中文名 | 8-OH-DPAT |
英文名 | S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT |
别名 | 化合物8-OH-DPAT |
英文别名 | 8-OH-DPAT 7-(dipropylamino)tetralin-1-ol 2-(Dipropylamino)tetralin-8-ol 8-Hydroxy-2-(di-n-propylamino)tetralin 5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT 2-(N,N-Dipropylamino)-1,2,3,4-tetrahydronaphthalen-8-ol 8-Hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene |
CAS | 78950-78-4 |
化学式 | C16H25NO |
分子量 | 247.38 |
存储条件 | -20℃ |
外观 | 固体 |
颜色 | white |
体外研究 | 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC 50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC 50 , 5.42), 5-HT (pIC 50 <5). 8-OH-DPAT has high affinity at 5-HT7 with a K i of 466 nM, and does not bind to 5-HT6 or 5-HT4. |
体内研究 | 8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
上游原料 | 8-甲氧基-3,4-二氢-1H-2-萘酮 二正丙胺 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.046 ml | 15.231 ml | 30.461 ml |
5 mM | 0.609 ml | 3.046 ml | 6.092 ml |
10 mM | 0.305 ml | 1.523 ml | 3.046 ml |
5 mM | 0.061 ml | 0.305 ml | 0.609 ml |
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