877874-85-6
KG-5(2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine)
CAS: 877874-85-6
化学式: C20H16F3N7OS
| 中文名 | KG-5 |
| 英文名 | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| 英文别名 | KG5 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine 4-Pyrimidinamine, 2-(methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]- |
| CAS | 877874-85-6 |
| 化学式 | C20H16F3N7OS |
| 分子量 | 459.45 |
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 沸点 | 654.0±65.0 °C(Predicted) |
| 酸度系数 | 9.54±0.40(Predicted) |
| 存储条件 | -20℃ |
| 产品用途 | KG5 是一种具有口服活性的双重 PDGFRβ 和 B-Raf 变构抑制剂。KG5 还抑制 Flt3，KIT 和 c-Raf，并具有抗癌，抗血管生成活性。 |
| 靶点 | PDGFRβ:520 nM (Kd);PDGFRα:300 nM (Kd);B-Raf;c-Raf;FLT3:52 nM (Kd);KIT:170 nM (Kd) |
| 参考资料 展开查看 | 1: Levine DM, Savarimuthu S, Squires A, Nicholson J, Jay M. Technology-assisted weight loss interventions in primary care: a systematic review. J Gen Intern Med. 2015 Jan;30(1):107-17. doi: 10.1007/s11606-014-2987-6. Epub 2014 Aug 19. Review. PubMed PMID: 25134692; PubMed Central PMCID: PMC4284284. 2: Li L, Tian JH, Yang K, Zhang P, Jia WQ. Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection. Cochrane Database Syst Rev. 2014 Jul 26;(7):CD008439. doi: 10.1002/14651858.CD008439.pub3. Review. PubMed PMID: 25063928. 3: Goring S, Hawkins N, Wygant G, Roudaut M, Townsend R, Wood I, Barnett AH. Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: a systematic review and network meta-analysis. Diabetes Obes Metab. 2014 May;16(5):433-42. doi: 10.1111/dom.12239. Epub 2013 Dec 16. Review. PubMed PMID: 24237939. 4: John GK, Douglas NM, von Seidlein L, Nosten F, Baird JK, White NJ, Price RN. Primaquine radical cure of Plasmodium vivax: a critical review of the literature. Malar J. 2012 Aug 17;11:280. doi: 10.1186/1475-2875-11-280. Review. PubMed PMID: 22900786; PubMed Central PMCID: PMC3489597. 5: Karbasi A, Karbasi-Afshar R, Ahmadi J, Saburi A. Retroperitoneal fibrosis as a result of signet ring cell gastric cancer: a case-based review. J Gastrointest Cancer. 2013 Mar;44(1):94-7. doi: 10.1007/s12029-012-9422-1. Review. PubMed PMID: 22851371. |
877874-85-6 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.177 ml | 10.883 ml | 21.765 ml |
| 5 mM | 0.435 ml | 2.177 ml | 4.353 ml |
| 10 mM | 0.218 ml | 1.088 ml | 2.177 ml |
| 5 mM | 0.044 ml | 0.218 ml | 0.435 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: KG 5,PDGFRβ,B-Raf,c-Raf,FLT3和KIT抑制剂 去供应商网站查看 询盘CAS: 877874-85-6
产地: 上海
规格: K970675
价格: 5mg-1287
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: KG 5,PDGFRβ,B-Raf,c-Raf,FLT3和KIT抑制剂 去供应商网站查看 询盘CAS: 877874-85-6
产地: 上海
规格: K970675
价格: 5mg-1287
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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