877874-85-6

877874-85-6 - Names and Identifiers

Name	2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
Synonyms	KG5 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine 4-Pyrimidinamine, 2-(methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-
CAS	877874-85-6

877874-85-6 - Physico-chemical Properties

Molecular Formula	C20H16F3N7OS
Molar Mass	459.45
Density	1.54±0.1 g/cm3(Predicted)
Boling Point	654.0±65.0 °C(Predicted)
pKa	9.54±0.40(Predicted)
Storage Condition	-20℃
Use	KG5 is a dual PDGFRβ and B- Raf allosteric inhibitor with oral activity. KG5 also inhibits Flt3,KIT and c-Raf, and has anti-cancer, anti-angiogenic activity.
Target	PDGFRβ:520 nM (Kd);PDGFRα:300 nM (Kd);B-Raf;c-Raf;FLT3:52 nM (Kd);KIT:170 nM (Kd)

877874-85-6 - Reference

Reference

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