887603-94-3
ST101(ST101)
CAS: 887603-94-3
化学式: C15H12N2O
| 中文名 | ST101 |
| 英文名 | ST101 |
| 别名 | 化合物ZSET-1446 1',3'-二氢-2H-螺[咪唑并[1,2-A]吡啶-3,2'-茚]-2-酮 |
| 英文别名 | ST101 ST-101 ST 101 ZSET 1446 ZSET-1446 ST 101(ZSET1446) 1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro- |
| CAS | 887603-94-3 |
| 化学式 | C15H12N2O |
| 分子量 | 236.27 |
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 沸点 | 403.4±55.0 °C(Predicted) |
| 酸度系数 | 3.13±0.20(Predicted) |
| 存储条件 | 2-8℃ |
| 体外研究 | ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 µM; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM. |
| 体内研究 | ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus. |
887603-94-3 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.232 ml | 21.162 ml | 42.324 ml |
| 5 mM | 0.846 ml | 4.232 ml | 8.465 ml |
| 10 mM | 0.423 ml | 2.116 ml | 4.232 ml |
| 5 mM | 0.085 ml | 0.423 ml | 0.846 ml |
最后更新：2024-01-02 23:10:35
887603-94-3 - 简介
ST101是一种常见的化学物质，化学名称为甲苯硫酸。它是无色至浅黄色的液体，具有特殊的臭味。ST101可溶于水、醇和醚等常见溶剂。
制备ST101的方法一般采用甲苯和硫酸的反应。将甲苯加入到硫酸中，加热反应，生成甲苯硫酸。随后，通过中和反应或蒸馏等步骤，可以得到纯度较高的ST101。
它属于腐蚀性和刺激性物质，应避免直接接触皮肤、眼睛和呼吸道。在操作过程中，应佩戴防护服、防护手套和防护眼镜等个人防护装备。要将其储存在阴凉、干燥和通风良好的地方，远离火源。
制备ST101的方法一般采用甲苯和硫酸的反应。将甲苯加入到硫酸中，加热反应，生成甲苯硫酸。随后，通过中和反应或蒸馏等步骤，可以得到纯度较高的ST101。
它属于腐蚀性和刺激性物质，应避免直接接触皮肤、眼睛和呼吸道。在操作过程中，应佩戴防护服、防护手套和防护眼镜等个人防护装备。要将其储存在阴凉、干燥和通风良好的地方，远离火源。
最后更新：2024-04-09 21:11:58
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