AM630
AM 630(AM 630)
CAS: 164178-33-0
化学式: C23H25IN2O3
| 中文名 | AM 630 |
| 英文名 | AM 630 |
| 别名 | (6-碘-2-甲基-1-(2-吗啉-4-基乙基)-1H-吲哚-3-基)(4-甲氧基苯基)甲酮 [6-碘-2-甲基-1-[2-(4-吗啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮 |
| 英文别名 | AM630 AM 630 AM-630 SC-200365(AM-630) Iodopravadoline (AM630) 1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole (6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone 6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE Methanone, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)- |
| CAS | 164178-33-0 |
| 化学式 | C23H25IN2O3 |
| 分子量 | 504.36 |
| 密度 | 1.49±0.1 g/cm3(Predicted) |
| 沸点 | 605.9±55.0 °C(Predicted) |
| 溶解度 | DMSO: >5 mg/mL |
| 酸度系数 | 6.98±0.10(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| 体外研究 | The AM251 and 6-Iodopravadoline (AM630)-evoked Ca 2+ influxes into TG sensory neurons aere concentration-dependent, and fitted. The EC 50 for AM251 and 6-Iodopravadoline are 7.37 μM and 15.6 μM, respectively. AM251 and 6-Iodopravadoline activate TRPA1 in TG sensory neurons. 6-Iodopravadoline is comparable in value in both TRPA1 and TRPV1/TRPA1 expressing CHO cells (2 and 4.6 μM, respectively). AM251 and 6-Iodopravadoline activation of TRPA1 is modulated by TRPV1. 6-Iodopravadoline (0, 50, 100, and 200 nM) is not toxic to RAW264.7 cells. 6-Iodopravadoline (100 nM) substantially inhibits osteoclastogenesis in cultures with RANKL and Ti particles in a dose-dependent manner. 6-Iodopravadoline (1 μM) blocks the CP-55,940 dose response with EC 50 of 170 nM at human and EC 50 of 110 nM at rat cannabinoid CB2 receptor. |
| 体内研究 | 6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.) significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day) produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used. |
| 危险品标志 | N - 危害环境的物品 |
| 风险术语 | 50 - 对水生生物有极高毒性。 |
| 安全术语 | 61 - 避免释放至环境中。参考特别说明/安全数据说明书。 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
AM630 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.983 ml | 9.914 ml | 19.827 ml |
| 5 mM | 0.397 ml | 1.983 ml | 3.965 ml |
| 10 mM | 0.198 ml | 0.991 ml | 1.983 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.397 ml |
最后更新：2024-01-02 23:10:35
供应商列表
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！