中文名 | AZD4320 |
英文名 | AZD4320 |
别名 | 化合物AZD4320 |
英文别名 | AZD4320 Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]- |
CAS | 1357576-48-7 |
化学式 | C45H48ClF3N4O7S3 |
分子量 | 945.53 |
密度 | 1.46±0.1 g/cm3(Predicted) |
溶解度 | DMSO: 125毫克/毫升 (132.20毫米; 需要超声波) |
酸度系数 | 4.70±0.10(Predicted) |
存储条件 | -20℃ |
靶点 | BCL2 BCLxL |
上游原料 | 1-PIPERIDINECARBOXYLIC ACID, 4-[(4'-CHLORO[1,1'-BIPHENYL]-2-YL)HYDROXYMETHYL]-, 1,1-DIMETHYLETHYL ES 3-苄氧羰基-4-苯硫基丁酸甲酯 2-溴-4'-氯-1,1'-联苯 1-氟-2-(三氟甲磺酰基)苯 4-氯苯硼酸 |
参考资料 展开查看 | 1. Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.058 ml | 5.288 ml | 10.576 ml |
5 mM | 0.212 ml | 1.058 ml | 2.115 ml |
10 mM | 0.106 ml | 0.529 ml | 1.058 ml |
5 mM | 0.021 ml | 0.106 ml | 0.212 ml |
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