AZD4320
AZD4320
CAS: 1357576-48-7
Molecular Formula: C45H48ClF3N4O7S3
AZD4320 - Names and Identifiers
| Name | AZD4320 |
| Synonyms | AZD4320 Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]- |
| CAS | 1357576-48-7 |
AZD4320 - Physico-chemical Properties
| Molecular Formula | C45H48ClF3N4O7S3 |
| Molar Mass | 945.53 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Solubility | DMSO : 125 mg/mL (132.20 mM; Need ultrasonic) |
| pKa | 4.70±0.10(Predicted) |
| Storage Condition | -20℃ |
| Target | BCL2 BCLxL |
AZD4320 - Reference
| Reference Show more | 1. Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21. |
AZD4320 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.058 ml | 5.288 ml | 10.576 ml |
| 5 mM | 0.212 ml | 1.058 ml | 2.115 ml |
| 10 mM | 0.106 ml | 0.529 ml | 1.058 ml |
| 5 mM | 0.021 ml | 0.106 ml | 0.212 ml |
Last Update：2024-01-02 23:10:35
AZD4320 - Note
AZD4320 is a novel analog of BH-3, a potent dual inhibitor of BCL2/BCLxL. The IC50 of AZD4320 for the KPUM-MS3,KPUM-UH1, and STR-428 cell lines were 26 nM,17 nM, and 170 nM, respectively.
Last Update：2023-08-16 21:32:38
