中文名 | Fenretinide |
英文名 | Fenretinide |
别名 | 酚维A胺 芬维A胺 维甲酰酚胺 维甲酸对羟基苯胺 结合珠蛋白相关蛋白抗体 全反式-N-(4-羟苯基)维甲酸 维甲酰酚胺FENRETINIDE |
英文别名 | 4HPR FENRETINIDE Fenretinide Fenretinimide Fenretinide(4-HPR) 4-HYDROXYPHENYLRETINAMIDE p-Hydroxyphenylretinamide 4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide (2E,4E,6E,8E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide |
CAS | 65646-68-6 |
EINECS | 200-256-5 |
化学式 | C26H33NO2 |
分子量 | 391.55 |
InChIKey | AKJHMTWEGVYYSE-FXILSDISSA-N |
密度 | 1.081±0.06 g/cm3(Predicted) |
熔点 | 162-163°C |
沸点 | 597.6±42.0 °C(Predicted) |
溶解度 | 氯仿 (微溶) 、甲醇 (微溶) |
酸度系数 | 9.98±0.26(Predicted) |
存储条件 | -20°C |
稳定性 | 光敏-防止曝光 |
敏感性 | Sensitive to heat and air |
外观 | 橙色固体 |
颜色 | Yellow |
最大波长(λmax) | 362nm(MeOH)(lit.) |
Merck | 14,3998 |
MDL号 | MFCD00792674 |
体外研究 | Fenretinide (4-HPR) exerts not just acute but also long term antitumor activity in selected T-ALL cell lines. Fenretinide inhibits DES activity in CCRF-CEM leukemia cells in a dose and time dependent manner, leading to a concomitant increase of the endogenous cellular dhCer content. Fenretinide (3 μM)-induced dhCer accumulation in both CCRF-CEM and Jurkat cells. Ceramide inhibition with fenretinide protects insulin signaling. Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake. Fenretinide inhibits OVCAR-5 cell proliferation and viability at concentrations higher than 1 microM, with 70-90% growth inhibition at 10 microM. Fenretinide (1 microM) significantly inhibits OVCAR-5 invasion after 3 days preincubation. Endothelial cells treated with 1 microM 4-HPR fails to form tubes, but forms small cellular aggregates. |
体内研究 | Fenretinide (4-HPR) (10 mg/kg, i.p.) selectively inhibits ceramide accumulation HFD-fed male C57Bl/6 mice. Fenretinide treatment improves glucose tolerance and insulin sensitivity as determined by both glucose and insulin tolerance tests. Addition of 25 mg/kg ketoconazole to Fenretinide in NOD/SCID mice increased 4-HPR plasma levels. |
危险品标志 | T - 有毒物品 |
风险术语 | R60 - 可能损害生育能力。 R61 - 可能对胎儿造成伤害。 R20/21/22 - 吸入、皮肤接触及吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S53 - 避免接触,使用前须获得特别指示说明。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S52 - 不宜在表面积大的区域内部使用。 |
WGK Germany | 3 |
RTECS | VH6420000 |
上游原料 | 4-氨基苯酚 |
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