L-2-氨基-3-苯基丙酸
L-苯丙氨酸(L-Phenylalanine)
CAS: 63-91-2;3617-44-5
化学式: C9H11NO2
性质
白色单斛片状、小叶状或针状结晶。283℃分解。 极微溶于乙醇、甲醇。
制法
将脱脂大豆用盐酸水解后，除去酸性氨基酸，用活性炭或脱色树脂吸附苯丙氨酸和酪氨酸。再用溶剂将苯丙氨酸溶出、分离即可。
用途
用于生化研究、培养基配制。
安全性
- 吸入、食入及接触有害。如误服本品，误服者有意识未发生痉挛，可使其饮1～2杯水以稀释，然后立即送医院。应穿戴防护用具。
- 以纸桶装，25kg/桶。远离强氧化剂。
| 中文名 | L-苯丙氨酸 |
| 英文名 | L-Phenylalanine |
| 别名 | 苯丙氨酸 L-苯丙氨酸 L-苯基丙胺酸 L-苯基丙氨酸 L-2-氨基苯丙酸 阿斯巴甜EP杂质C 苯丙氨酸 (PHE) L-Α-氨基氢化肉桂酸 苯丙氨酸溶液 (PHE) L-2-氨基-3-苯基丙酸 L-苯丙氨酸, 非动物源,EP,JP,USP L-苯丙氨酸AJI88,USP23,FCCIII,CP2000 |
| 英文别名 | PHE H-Phe-OH H-L-PHE-OH Phenylalanine L-Phenylalanie L-Phenylalanin L-Phenylalanine Phenyalanine, L- Phenylalanine, L- L-Alanine, phenyl- L(-)Phenylalaniline L-Antibiotic FN 1636 L-beta-Phenylalanine (S)-(-)-Phenylalanine l-beta-phenyl-alpha-alanin L-AminobenzenepropanoicAcid L-α-Amino-β-phenyl-propionsαure (S)-2-Amino-3-Phenylpropionic acid (S)-(-)-PHENYLALANINE FOR SYNTHESIS (S)-2-Amino-3-phenylpropionic acid~H-Phe-OH |
| CAS | 63-91-2 3617-44-5 |
| EINECS | 200-568-1 |
| 化学式 | C9H11NO2 |
| 分子量 | 165.19 |
| InChI | InChI:1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12) |
| InChIKey | COLNVLDHVKWLRT-QMMMGPOBSA-N |
| 密度 | 1.29 |
| 熔点 | 270-275°C (dec.)(lit.) |
| 沸点 | 293.03°C (rough estimate) |
| 比旋光度 | -34.1 º (c=2, water, dry basis) |
| 闪点 | 153.1°C |
| 水溶性 | 1-5 g/100 mL at 25 ºC |
| 蒸汽压 | <1 Pa (25 °C) |
| JECFA Number | 1428 |
| 溶解度 | H2O: 0.1M，20 °C，澄清，无色 |
| 折射率 | -34 ° (C=2, H2O) |
| 酸度系数 | 2.2(at 25℃) |
| PH值 | 5.0-7.0 (25℃, 0.1M in H2O) |
| 存储条件 | Store below +30°C. |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 敏感性 | Sensitive to light |
| 外观 | 粉末 |
| 颜色 | White to off-white |
| Merck | 14,7271 |
| BRN | 1910408 |
| 物化性质 | 无色至白色片状晶体或白色结晶性粉末。略有特殊气味和苦味。约于283℃熔化并分解。10%水溶液的pH值为5.4～6.0。在受热、光照、空气中稳定。与葡萄糖一起加热则着色。碱性下不稳定。溶于水(3g/100ml，25℃)。难溶于乙醇、稀无机酸和碱性溶液。必需氨基酸之一。其生理作用与酪氨酸有关。可影响甲状腺激素和毛发、皮肤的黑色素。D-型与L-型的生理效果相同。最低需要量(mg/kg?d)：成人男子31；幼儿169。 |
| MDL号 | MFCD00064227 |
| 危险品标志 | C - 腐蚀性物品 |
| 风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R34 - 引起灼伤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S37/39 - 戴适当的手套和护目镜或面具。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S27 - 一旦衣物受到污染，请立即脱去。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| WGK Germany | 3 |
| RTECS | AY7535000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| 海关编号 | 29224995 |
| 上游原料 | L-精氨酸 Boc-D-酪氨酸 苯丙氨酯 N-苄氧羰基-DL-亮氨酸 |
| 下游产品 | DL-色氨酸 DL-苯丙氨酸 [MET5]脑啡肽 BOC-L-苯丙氨酸 |
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L-2-氨基-3-苯基丙酸 - 性质
可信数据
白色单斛片状、小叶状或针状结晶。283℃分解。 极微溶于乙醇、甲醇。
最后更新：2024-01-02 23:10:35
L-2-氨基-3-苯基丙酸 - 制法
可信数据
将脱脂大豆用盐酸水解后，除去酸性氨基酸，用活性炭或脱色树脂吸附苯丙氨酸和酪氨酸。再用溶剂将苯丙氨酸溶出、分离即可。
最后更新：2022-01-01 09:26:27
L-2-氨基-3-苯基丙酸 - 标准
可信数据
本品为L-2-氨基-3-苯基丙酸。按干燥品计算，含C9H1N02不得少于 98.5 % 。
最后更新：2024-01-02 23:10:35
L-2-氨基-3-苯基丙酸 - 性状
可信数据
- 本品为白色结晶或结晶性粉末；无臭。
- 本品在热水中溶解，在水中略溶，在乙醇中不溶；在稀酸或氢氧化钠试液中易溶。
比旋度
取本品，精密称定，加水溶解并定量稀释制成每lml中约含20mg的溶液，依法测定（通则0621)，比旋度为—33.0°至一35.0°。
最后更新：2022-01-01 13:33:35
L-2-氨基-3-苯基丙酸 - 用途
可信数据
用于生化研究、培养基配制。
最后更新：2022-01-01 09:26:27
L-2-氨基-3-苯基丙酸 - 鉴别
可信数据
- 取本品与苯丙氨酸对照品各适量，分别加冰醋酸溶液（50-100)溶解并稀释制成每lml中约含lOmg的溶液,作为供试品溶液与对照品溶液。照其他氨基酸项下的色谱条件试验，供试品溶液所显主斑点的位置和颜色应与对照品溶液的主斑点相同。
- 本品的红外光吸收图谱应与对照的图谱（光谱集983图）一致。
最后更新：2022-01-01 13:33:35
L-2-氨基-3-苯基丙酸 - 安全性
可信数据
- 吸入、食入及接触有害。如误服本品，误服者有意识未发生痉挛，可使其饮1～2杯水以稀释，然后立即送医院。应穿戴防护用具。
- 以纸桶装，25kg/桶。远离强氧化剂。
最后更新：2022-01-01 10:54:49
L-2-氨基-3-苯基丙酸 - 检查
可信数据
酸度
取本品0.20g,加水20ml溶解后，依法测定(通则0631),pH值应为5.4〜6.0。
溶液的透光率
取本品0.50g,加水25ml溶解后，照紫外-可见分光光度法（通则0401)，在430nm的波长处测定透光率，不得低于98.0% 。
氯化物
取本品0.30g,依法检查（通则0801),与标准氯化钠溶液6.Oml制成的对照液比较，不得更浓（0.02% ) 。
硫酸盐
取本品0.70g,依法检査（通则0802)，与标准硫酸钾溶液1.4ml制成的对照液比较,不得更浓(0.02% ) 。
铵盐
取本品0.10g,依法检査（通则0808),与标准氯化铵溶液2.Oml制成的对照液比较，不得更深(0.02% ) 。
其他氨基酸
取本品适量，加冰醋酸溶液（50—100)溶解并稀释制成每lml中约含lOmg的溶液，作为供试品溶液；精密量取lml,置200ml量瓶中，用水稀释至刻度，摇匀，作为对照溶液；另取苯丙氨酸对照品和酪氨酸对照品各适量，置同一量瓶中，加适量冰醋酸溶液（50—100)溶解，用水稀释制成每lml中约含苯丙氨酸lOmg和酪氨酸0.lmg的溶液，作为系统适用性溶液。照薄层色谱法（通则0502)试验，吸取上述三种溶液各5ul,分别点于同一硅胶G 薄层板上，以正丁醇-冰醋酸-水（6:2:2)为展开剂，展开,晾干，喷以茚三酮的丙酮溶液（1—50)，在90°C加热至斑点出现，立即检视。对照溶液应显一个清晰的斑点，系统适用性溶液应显两个完全分离的斑点。供试品溶液如显杂质斑点，其颜色与对照溶液的主斑点比较,不得更深(0.5% ) 。
干燥失重
取本品，在105°C干燥3小时，减失重量不得过 0.2% (通则 0831)。
炽灼残渣
取本品l.Og,依法检查（通则0841)，遗留残渣不得过0.1 % 。
铁盐
取本品l.Og，依法检査（通则0807)，与标准铁溶液1.0ml制成的对照液比较，不得更深（0.001% ) 。
重金属
取炽灼残渣项下遗留的残渣，依法检查（通则0821第二法），含重金属不得过百万分之十。
砷盐
取本品2.0g，加水23ml溶解后，加盐酸5ml，依法检查（通则0822第一法），应符合规定（0.0001% ) 。
细菌内毒素
取本品，加人内毒素检査用水，置温水浴中加热使其溶解，依法检查（通则1143)，每lg苯丙氨酸中含内毒素的量应小于25EU。（供注射用）
最后更新：2022-01-01 13:33:36
L-2-氨基-3-苯基丙酸 - 含量测定
可信数据
取本品约0.13g，精密称定,加无水甲酸3ml溶解后,加冰醋酸50ml,照电位滴定法(通则0701),用高氣酸滴定液(O.lmol/L)滴定,并将滴定的结果用空白试验校正。每lml离氯酸滴定液(0.lmol/L)相当于16.52mg的C9H1N02。
最后更新：2022-01-01 13:33:37
L-2-氨基-3-苯基丙酸 - 类别
可信数据
氨基酸类药。
最后更新：2022-01-01 13:33:37
L-2-氨基-3-苯基丙酸 - 贮藏
可信数据
密封保存。
最后更新：2022-01-01 13:33:37
L-2-氨基-3-苯基丙酸 - 简介
L-苯丙氨酸是一种氨基酸，也被称为L-phenylalanine。以下是关于L-苯丙氨酸的性质、用途、制法和安全信息的介绍：
性质：
外观：L-苯丙氨酸是无色或白色结晶粉末。
溶解性：可溶于水和酸性溶液，不溶于乙醇、醚等有机溶剂。
化学性质：L-苯丙氨酸是一个手性分子，有两个对映异构体（D-型和L-型）。人体只能吸收和利用L-苯丙氨酸。
用途：
营养补充品：L-苯丙氨酸是一种必需氨基酸，可以作为膳食补充剂用于改善营养状态。
制法：
L-苯丙氨酸主要通过生物合成方法制备，通常使用微生物或植物提取。其中最常用的方法是利用微生物发酵法，通过微生物菌种在合成养分条件下生产L-苯丙氨酸。
安全信息：
L-苯丙氨酸在正常使用情况下，通常是安全的。过量摄入可能引起一些不良反应，如头晕、恶心、呕吐等。对于乳糖不耐受的人群或患有苯酮尿症的人群，应避免使用L-苯丙氨酸补充剂。
性质：
外观：L-苯丙氨酸是无色或白色结晶粉末。
溶解性：可溶于水和酸性溶液，不溶于乙醇、醚等有机溶剂。
化学性质：L-苯丙氨酸是一个手性分子，有两个对映异构体（D-型和L-型）。人体只能吸收和利用L-苯丙氨酸。
用途：
营养补充品：L-苯丙氨酸是一种必需氨基酸，可以作为膳食补充剂用于改善营养状态。
制法：
L-苯丙氨酸主要通过生物合成方法制备，通常使用微生物或植物提取。其中最常用的方法是利用微生物发酵法，通过微生物菌种在合成养分条件下生产L-苯丙氨酸。
安全信息：
L-苯丙氨酸在正常使用情况下，通常是安全的。过量摄入可能引起一些不良反应，如头晕、恶心、呕吐等。对于乳糖不耐受的人群或患有苯酮尿症的人群，应避免使用L-苯丙氨酸补充剂。
最后更新：2024-04-09 21:04:16
供应商列表
现货供应
产品名: L-苯丙氨酸 去供应商网站查看 询盘CAS: 63-91-2
产地: 北京
包装: 瓶
规格: P0010-10g,10g,SP8210-200mg,200mg,IP0190-W-1ml,10mM*1ml( in Water),IP0190-200mg,200mg,IP0190-1g,1g
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: L-Phenylalanine 去供应商网站查看 询盘CAS: 63-91-2
产地: 美国
包装: 10 mg;25 mg;50 mg;100 mg
规格: HY-N0215R
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
现货供应
产品名: L-苯丙氨酸 去供应商网站查看 询盘CAS: 63-91-2
产地: 北京
包装: 瓶
规格: P0010-10g,10g,SP8210-200mg,200mg,IP0190-W-1ml,10mM*1ml( in Water),IP0190-200mg,200mg,IP0190-1g,1g
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: L-Phenylalanine 去供应商网站查看 询盘CAS: 63-91-2
产地: 美国
包装: 10 mg;25 mg;50 mg;100 mg
规格: HY-N0215R
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
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