L-精氨酸
L-精氨酸(L-Arginine)
CAS: 74-79-3
化学式: C6H14N4O2
性质
- 本品为白色的结晶性粉末。能溶于水(15%，21℃)，微溶于醇，不溶于醚。水溶液显碱性反应，能从空气中吸收二氧化碳。238℃分解。
- 精氨酸是人体半必需氨基酸，即在人体内合成能力较低，需部分从食物中补充，但是维持婴儿生长发育必不可少的氨基酸。在体内它是鸟氨酸循环的中间代谢产物，可促使尿素的生成和排泄，纠正氨中毒而能解除肝昏迷。精氨酸也是精子蛋白的主要成分，有促进精子生成，提高精子运动能量的作用。广泛存在于猪毛、蹄甲、血粉、明胶、鱼精蛋白、小杂鱼中。
制法
- 提取法。
- 发酵法。
用途
- 氨基酸类药。用于各类肝昏迷忌用谷氨酸钠者和病毒性肝类谷丙转氨酶异常者。
- 用法及剂量 静滴每日15～20g，以5%葡萄糖注射液lOOOmL稀释后静滴，4h内滴完，口服0.75～1. 5g -次，每日3次。用于男性不育症口服3个月为一疗程，每日4g。
安全性
- 对肾功能减退及无尿患者或大剂量使用时，应注意高氯性酸中毒的发生。滴注太快可引起流涎、面部潮红及呕吐等。肾功能不全或无尿者慎用或禁用。爆发型肝功能衰竭者，体内缺乏精氨酸酶，不宜使用。肝功能不良时，鸟氨酸循环中所需的酶活性降低，本品降血氨作用不明显。
- 遮光，密闭保存。
| 中文名 | L-精氨酸 |
| 英文名 | L-Arginine |
| 别名 | 精氨酸 L-精氨酸 胍基戊氨酸 精氨酸-左旋 L-精氨酸碱 L-蛋白氨基酸 L-胍基戊氨酸 2-氨基-5-胍基戊酸 L-2-氨基-胍基戊酸 |
| 英文别名 | Arg ABL2 FLJ31718 FLJ22224 Arginine FLJ41441 H-Arg-OH L-Arginine L(+)Arginine L(+)-Arginine L-Arginine base Abelson tyrosine-protein kinase 2 2-amino-5-guanidino-pentanoic acid L-2-Amino-5-guanidinopentanoic acid ANTI-ABL2 antibody produced in mouse (S)-2-Amino-5-guanidinopentanoic acid (S)-2-amino-5-guanidino-pentanoic acid ABL2 (38-end), active, His tagged human Abelson murine leukemia viral oncogene homolog 2 (2S)-5-{[amino(iminio)methyl]amino}-2-ammoniopentanoate |
| CAS | 74-79-3 |
| EINECS | 200-811-1 |
| 化学式 | C6H14N4O2 |
| 分子量 | 174.2 |
| InChI | InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 |
| InChIKey | ODKSFYDXXFIFQN-BYPYZUCNSA-N |
| 密度 | 1.2297 (rough estimate) |
| 熔点 | 222 °C (dec.) (lit.) |
| 沸点 | 305.18°C (rough estimate) |
| 比旋光度 | 27.1 º (c=8, 6N HCl) |
| 闪点 | 201.2°C |
| 水溶性 | 148.7 g/L (20 ºC) |
| 蒸汽压 | 7.7E-08mmHg at 25°C |
| JECFA Number | 1438 |
| 溶解度 | H2O: 100 mg/mL |
| 折射率 | 27 ° (C=8, 6mol/L HC |
| 酸度系数 | 1.82, 8.99, 12.5(at 25℃) |
| PH值 | 10.5-12.0 (25℃, 0.5M in H2O) |
| 存储条件 | 2-8°C |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 敏感性 | Air Sensitive |
| 外观 | 粉末 |
| 颜色 | white |
| 最大波长(λmax) | ['λ: 260 nm Amax: ≤0.2', , 'λ: 280 nm Amax: ≤0.1'] |
| Merck | 14,780 |
| BRN | 1725413 |
| 物化性质 | 白色菱形结晶 (从水中析出，含2分子结晶水)或单斜片状结晶(无结晶水)，无臭，味苦；易溶于水(0℃水中溶解度为83g/L，50℃水中溶解度为 400g/L)，极微溶于乙醇，不溶于乙醚；pI6.0；加热至105℃时失去两分子结晶水，230℃时颜色变深，分解点为244℃；比旋光度[α]20D+12.5°(0.5-2.0mg/ml，H2O)，[α]20D+27.3°(0.5-2.0mg/ml，6mol/L HCl)；水溶液在205nm处有最大吸收(1gε3.28)。 |
| MDL号 | MFCD00002635 |
| 危险品标志 | Xn - 有害物品 T - 有毒物品  |
| 风险术语 | R36 - 刺激眼睛。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R20/21/22 - 吸入、皮肤接触及吞食有害。 R61 - 可能对胎儿造成伤害。 |
| 安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S53 - 避免接触，使用前须获得特别指示说明。 S39 - 戴护目镜或面具。 |
| WGK Germany | 3 |
| RTECS | CF1934200 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| 海关编号 | 29252000 |
| Hazard Class | IRRITANT |
| 上游原料 | 明胶 |
| 下游产品 | L-精氨酸-α-酮戊二酸盐 |
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[IF=2.281] Zihui Ma et al."Studies on the biosynthetic pathways of melanin in Auricularia auricula."JOURNAL OF BASIC MICROBIOLOGY 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 储存条件： 2-8℃ 敏感性： 对光敏感 溶解性： 溶于水，微溶于乙醇，不溶于乙醚 外观： 粉末 比旋光度： 27.1 o (C=8, 6N HCL) 沸点： 409.1 °C at 760 mmHg 熔点： 222°C 天然精氨酸有两种同分异构体，左旋（L-）和右旋（D-），动物体内主要是L-精氨酸。可作为细胞培养MEM氨基酸溶液组分之一。 L-精氨酸在体外哺乳动物细胞培养的生长和传代起着重要的作用。在不更换细胞培养基情况下，L-精氨酸能保持细胞增殖的活跃率。 L-精氨酸（L-Arginine）在体内经鸟氨酸循环合成。精氨酸可转化为谷氨酸盐，进一步转化为α-酮戊二酸进入三羧酸循环。在一氧化氮合成酶的作用下，可转化为瓜氨酸和一氧化氮 (NO)，进而通过与一氧化氮相关的机理诱导胰岛素释放。 生物活性 |
L-精氨酸 - 性质
可信数据
- 本品为白色的结晶性粉末。能溶于水(15%，21℃)，微溶于醇，不溶于醚。水溶液显碱性反应，能从空气中吸收二氧化碳。238℃分解。
- 精氨酸是人体半必需氨基酸，即在人体内合成能力较低，需部分从食物中补充，但是维持婴儿生长发育必不可少的氨基酸。在体内它是鸟氨酸循环的中间代谢产物，可促使尿素的生成和排泄，纠正氨中毒而能解除肝昏迷。精氨酸也是精子蛋白的主要成分，有促进精子生成，提高精子运动能量的作用。广泛存在于猪毛、蹄甲、血粉、明胶、鱼精蛋白、小杂鱼中。
最后更新：2024-01-02 23:10:35
L-精氨酸 - 制法
可信数据
- 提取法。
- 发酵法。
最后更新：2022-01-01 11:10:12
L-精氨酸 - 介绍
一氧化氮合成酶的底物，可转化为瓜氨酸和一氧化氮 (NO)。通过与一氧化氮相关的机理诱导胰岛素释放。
最后更新：2022-10-16 17:28:15
L-精氨酸 - 用途
可信数据
- 氨基酸类药。用于各类肝昏迷忌用谷氨酸钠者和病毒性肝类谷丙转氨酶异常者。
- 用法及剂量 静滴每日15～20g，以5%葡萄糖注射液lOOOmL稀释后静滴，4h内滴完，口服0.75～1. 5g -次，每日3次。用于男性不育症口服3个月为一疗程，每日4g。
最后更新：2022-01-01 11:10:13
L-精氨酸 - 安全性
可信数据
- 对肾功能减退及无尿患者或大剂量使用时，应注意高氯性酸中毒的发生。滴注太快可引起流涎、面部潮红及呕吐等。肾功能不全或无尿者慎用或禁用。爆发型肝功能衰竭者，体内缺乏精氨酸酶，不宜使用。肝功能不良时，鸟氨酸循环中所需的酶活性降低，本品降血氨作用不明显。
- 遮光，密闭保存。
最后更新：2022-01-01 11:10:13
L-精氨酸 - 简介
L-精氨酸是一种氨基酸，是人体内必需的氨基酸之一。它主要存在于肌肉和神经系统中。L-精氨酸的化学结构是一种二元氨基酸，具有两个氨基和一个丙氨酸侧链。L-精氨酸具有以下性质和用途：
性质：
1、大部分L-精氨酸以无色结晶体的形式存在，可溶于水和酸性溶液。
2、L-精氨酸呈鹰嘴豆味，具有碱性。
3、L-精氨酸在高温条件下易于分解。
用途：
1、L-精氨酸在体内与甲硫氨酸反应生成辅酶A，参与能量代谢过程。
2、L-精氨酸作为营养补充剂可用于增加肌肉质量和力量，被广泛应用于体育锻炼和肌肉恢复。
制法：
L-精氨酸的主要制法是通过微生物发酵生产。通常使用大豆蛋白、玉米浆或糖蜜作为原料，通过添加适当的微生物菌种进行发酵，之后经过提纯和结晶等步骤得到纯度较高的L-精氨酸。
安全信息：
1、L-精氨酸在一般情况下对人体是安全的，但有些人可能会对其过敏。
2、长期大量摄取可能导致恶心、呕吐等胃肠道不适症状。
3、在使用L-精氨酸补充剂时，应按照医生或专业人士的指导服用适当剂量。
4、对于孕妇、哺乳期的妇女和婴儿，应谨慎使用。
最后更新：2024-09-26 08:48:40
供应商列表
提供多种规格
产品名: L-精氨酸 紫外分光标准品 去供应商网站查看 询盘CAS: 74-79-3
产地: 北京
包装: 500mg /瓶
规格: SVA1305-500mg
价格: 电话、微信、QQ、邮件
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
提供多种规格
产品名: L-精氨酸 紫外分光标准品 去供应商网站查看 询盘CAS: 74-79-3
产地: 北京
包装: 500mg /瓶
规格: SVA1305-500mg
价格: 电话、微信、QQ、邮件
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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