LY223982
LY223982(LY223982)
CAS: 117423-74-2
化学式: C30H30O7
| 中文名 | LY223982 |
| 英文名 | LY223982 |
| 别名 | 化合物 T15803 |
| 英文别名 | CGS23131 LY223982 LY 223982 SKF107324) 117423-74-2 LY223982 Exclusive SYZSSLLFRVDRHL-QPJJXVBHSA-N 5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]- |
| CAS | 117423-74-2 |
| 化学式 | C30H30O7 |
| 分子量 | 502.55 |
| 密度 | 1.235±0.06 g/cm3(Predicted) |
| 熔点 | 151-152 °C |
| 沸点 | 753.8±60.0 °C(Predicted) |
| 溶解度 | 氯仿 (轻微，加热，超声处理)，DMSO (非常轻微) |
| 酸度系数 | 3.81±0.10(Predicted) |
| 存储条件 | -20°C Freezer |
| 体外研究 | LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC 50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC 50 , 100 nM). |
| 体内研究 | LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED 50 , 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems. |
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