中文名 | 樱桃甙;洋李甙 |
英文名 | Prunin |
别名 | 樱桃甙 普鲁宁 樱桃甙;洋李甙 柚皮素单葡萄糖苷 柚皮素-7-O-葡萄糖苷 柚(苷)配基-7-O-葡糖苷 柚皮素-7-O-葡萄糖苷(樱桃苷) |
英文别名 | Prunin PRUNIN -7-(((2S,3R,4S,5S,6R) NARINGENIN-7-GLUCOSIDE NARINGENIN-7-O-GLUCOSIDE (-)-Naringenin 7-b-D-glucoside 4',5-DIHYDROXY-7-GLUCOSYLOXYFLAVANONE (S)-7-(beta-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (R)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)chroMan-4-one |
CAS | 529-55-5 |
EINECS | 208-464-8 |
化学式 | C21H22O10 |
分子量 | 434.4 |
密度 | 1.597±0.06 g/cm3(Predicted) |
熔点 | 222-224°C |
沸点 | 802.4±65.0 °C(Predicted) |
比旋光度 | -41.8 (Me2CO) |
溶解度 | 溶于甲醇,氯仿 |
酸度系数 | 7.18±0.40(Predicted) |
存储条件 | Sealed in dry,Store in freezer, under -20°C |
体外研究 | Prunin exhibited dose-dependent inhibitory activity against ONOO--mediated tyrosine nitration and stimulated glucose uptake by decreasing PTP1B expression level in insulin-resistant HepG2 cells. Prunin shows significant inhibitory activity against α-glucosidase, with an IC 50 of 317 ± 2.12 µM. |
危险品标志 | N - 危害环境的物品 |
风险术语 | R22 - 吞食有害。 R50 - 对水生生物有极高毒性。 |
安全术语 | S22 - 切勿吸入粉尘。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S61 - 避免释放至环境中。参考特别说明/安全数据说明书。 |
危险品运输编号 | UN 3077 9 / PGIII |
WGK Germany | 3 |
参考资料 展开查看 | 1. 王维娜,李佥,田晶,费旭,徐龙权,廉萌.黑曲霉液态发酵产柚苷酶的分离纯化及其性质研究[J].现代食品科技,2016,32(07):72-78+46. 2. 邬子彬, 胡基志, 羌宇,等. 黑曲霉所产α-L-鼠李糖苷酶制备普鲁宁[J]. 南昌大学学报(理科版), 2017, 41(06):55-60. 3. Mi, Nan, et al. "Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: an integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical analysis." Journal of pharmaceutical and biomedical analysis 164 (2019): 70-85 4. Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https://doi.org/10.1016/ 5. [IF=5.645] Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 6. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;: 7. [IF=2.926] Li Bin-Chun et al."Target Discovery of Novel α-l-Rhamnosidases from Human Fecal Metagenome and Application for Biotransformation of Natural Flavonoid Glycosides."Appl Biochem Biotech. 2019 Dec;189(4):1245-1261 |
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