Silvestrol_化工百科

中文名	Silvestrol
英文名	Silvestrol
别名	化合物 T16884 (1R,2R,3S,3AR,8BS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-二羟基乙基]-3-甲氧基-1,4-二氧己环-2-基]氧基]-2,3,3A,8B-四氢-1,8B-二羟基-8-甲氧基-3A-(4-甲氧基苯基)-3-苯基-1H-环戊烯并[B]苯并呋喃-2-羧酸甲酯
英文别名	Silvestrol (-)-Silvestrol (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester 1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-Methoxy-1,4-dioxan-2-yl]o xy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-Methoxy-3a-(4-Methoxypheny l)-3-phenyl-, Methyl ester, (1R,2R,3S,3aR,8bS)-
CAS	697235-38-4
化学式	C34H38O13
分子量	654.66
密度	1.45
熔点	120-122℃
沸点	800.8±65.0 °C(Predicted)
酸度系数	11.57±0.70(Predicted)
存储条件	-20℃
体外研究	Silvestrol is a specific eIF4A-targeting translation inhibitor. Silvestrol exhibits significant cytotoxic activity against many human cancer cell lines, such as lung, prostate, and breast cancer with IC 50 values ranging from 1 to 7 nM. Silvestrol significantly reduces the number of LNCaP cell colonies. Silvestrol (30 nM, 120 nM) induces apoptosis in LNCaP cells, through the mitochondrial pathway. Apaf-1, Caspase-2, caspase-9, and caspase-10 are involved in Silvestrol-induced apoptosis but caspase-3 and 7 are not. Silvestrol induces caspase-3 activation and apoptotic cell death in a time- and dose-dependent manner. Silvestrol-mediated cell death is attenuated in ATG7-null mouse embryonic fibroblasts (MEFs) lacking a functional autophagy protein. Silvestrol (50 nM) exerts an immediate inhibitory effect and causes near-static cell index compared with the control cells. Silvestrol (6.25 nM) enhances proliferation more than the vehicle control-treated cells, whereas a higher concentration of Silvestrol (50 nM) can inhibit cell proliferation. Silvestrol and episilvestrol display synergistic effects in combination with CDDP.
体内研究	Silvestrol (1.5 mg/kg, i.p.) does not adversely affect production of human IgG by xenografted B-lymphocytes in mice. Silvestrol significantly prolongs survival compared to vehicle. There is no such lymphocyte infiltration detected in the spleens of any of the Silvestrol-treated mice, and nor do these animals exhibit any other obvious signs of lymphoma upon necropsy.

Silvestrol - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.528 ml	7.638 ml	15.275 ml
5 mM	0.306 ml	1.528 ml	3.055 ml
10 mM	0.153 ml	0.764 ml	1.528 ml
5 mM	0.031 ml	0.153 ml	0.306 ml

最后更新：2024-01-02 23:10:35

Silvestrol - 简介

Silvestrol是一种天然产物，来源于银杏树（Silv

最后更新：2024-04-09 02:00:01

北京索莱宝科技有限公司

现货供应

产品名: Silvestrol 去供应商网站查看询盘
CAS: 697235-38-4
产地: 北京
包装: 盒
规格: IS3580-1mg,1mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
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QQ: 3193328036

微信: 17801761073
产品描述: 索莱宝直销，欢迎来询

上海吉至生化科技有限公司

现货供应

产品名: Silvestrol 去供应商网站查看询盘
CAS: 697235-38-4
产地: 中国上海
包装: 2mg
规格: 98%
价格: 16498.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名：Silvestrol 英文名:Silvestrol CAS:697235-38-4 规格:98% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: (-)-Silvestrol 去供应商网站查看询盘
CAS: 697235-38-4
产地: 上海
规格: S860715
价格: 1mg-13890
库存: 15天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191