Silvestrol
Silvestrol
CAS: 697235-38-4
Molecular Formula: C34H38O13
Silvestrol - Names and Identifiers
Silvestrol - Physico-chemical Properties
| Molecular Formula | C34H38O13 |
| Molar Mass | 654.66 |
| Density | 1.45 |
| Melting Point | 120-122℃ |
| Boling Point | 800.8±65.0 °C(Predicted) |
| pKa | 11.57±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Silvestrol is a specific eIF4A-targeting translation inhibitor. Silvestrol exhibits significant cytotoxic activity against many human cancer cell lines, such as lung, prostate, and breast cancer with IC 50 values ranging from 1 to 7 nM. Silvestrol significantly reduces the number of LNCaP cell colonies. Silvestrol (30 nM, 120 nM) induces apoptosis in LNCaP cells, through the mitochondrial pathway. Apaf-1, Caspase-2, caspase-9, and caspase-10 are involved in Silvestrol-induced apoptosis but caspase-3 and 7 are not. Silvestrol induces caspase-3 activation and apoptotic cell death in a time- and dose-dependent manner. Silvestrol-mediated cell death is attenuated in ATG7-null mouse embryonic fibroblasts (MEFs) lacking a functional autophagy protein. Silvestrol (50 nM) exerts an immediate inhibitory effect and causes near-static cell index compared with the control cells. Silvestrol (6.25 nM) enhances proliferation more than the vehicle control-treated cells, whereas a higher concentration of Silvestrol (50 nM) can inhibit cell proliferation. Silvestrol and episilvestrol display synergistic effects in combination with CDDP. |
| In vivo study | Silvestrol (1.5 mg/kg, i.p.) does not adversely affect production of human IgG by xenografted B-lymphocytes in mice. Silvestrol significantly prolongs survival compared to vehicle. There is no such lymphocyte infiltration detected in the spleens of any of the Silvestrol-treated mice, and nor do these animals exhibit any other obvious signs of lymphoma upon necropsy. |
Silvestrol - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.528 ml | 7.638 ml | 15.275 ml |
| 5 mM | 0.306 ml | 1.528 ml | 3.055 ml |
| 10 mM | 0.153 ml | 0.764 ml | 1.528 ml |
| 5 mM | 0.031 ml | 0.153 ml | 0.306 ml |
Last Update：2024-01-02 23:10:35
Silvestrol - Reference Information
| Biological activity | Silvestrol is an inhibitor of eukaryotic translation initiation factor (eIF4A) isolated from fruits and branches of Aglaia foveolata. Silvestrol induces autophagy and caspase-mediated apoptosis. |
| target | eIF4A |
| in vitro study | Silvestrol is a specific eIF4A-targeting translation inhibitor. Silvestrol exhibits significant cytotoxic activity against many human cancer cell lines, such as lung, prostate, and breast cancer with IC 50 values ranging from 1 to 7 nM. Silvestrol significantly reduces the number of LNCaP cell colonies. Silvestrol (30 nM, 120 nM) induces apoptosis in LNCaP cells, through the mitochondrial pathway. Apaf-1, Caspase-2, caspase-9, and caspase-10 are involved in Silvestrol-induced apoptosis but caspase-3 and 7 are not. Silvestrol induces caspase-3 activation and apoptotic cell death in a time- and dose-dependent banner. Silvestrol-mediated cell death is attenuated in ATG7-null mouse embryonic fibroblasts (MEFs) lacking a functional autophagy protein. Silvestrol (50 nM) exerts an immediate inhibitory effect and cause near-static cell index compared with the control cells. Silvestrol (6.25 nM) enhances proliferation more than the vehicle control-treated cells, whereas a higher concentration of Silvestrol (50 nM) can inhibit cell proliferation. Silvestrol and episilvestrol display synergistic effects in combination with CDDP. |
| in vivo study | Silvestrol (1.5 mg/kg, I. p.) does not adversely effect production of human IgG by xenografted B- lymphocytes in mice. Silvestrol significantly prolongs survival compared to vehicle. There is no such lymphocyte infiltration detected in the spleens of any of the Silvestrol-treated mice, and nor do these animals exhibit any other obvious signs of lymphoma upon necropsy. |
Last Update：2024-04-09 02:00:01
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Product Name: Silvestrol Visit Supplier Webpage Request for quotation
CAS: 697235-38-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 697235-38-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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