Vonafexor
Vonafexor(4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid)
CAS: 1192171-69-9
化学式: C19H15Cl3N2O5S
| 中文名 | Vonafexor |
| 英文名 | 4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid |
| 别名 | 化合物VONAFEXOR |
| 英文别名 | YP001 PXL007 PLX007 EYP-001 Vonafexor Vonafexor(PLX007,EYP-001) 2-Benzofurancarboxylic acid, 4-chloro-5-[4-[(2,6-dichlorophenyl)sulfonyl]-1-piperazinyl]- 4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid |
| CAS | 1192171-69-9 |
| 化学式 | C19H15Cl3N2O5S |
| 分子量 | 489.76 |
| 密度 | 1.604±0.06 g/cm3(Predicted) |
| 沸点 | 680.5±65.0 °C(Predicted) |
| 溶解度 | 溶于DMSO |
| 酸度系数 | 3.05±0.30(Predicted) |
| 存储条件 | -20℃ |
| 产品用途 | Vonafexor, also known as EYP001, is a farnesoid X receptor agonist. Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) for which therapy is suboptimal. The farnesoid-X-receptor (FXR) and the G protein bile acid receptor (GPBAR)1 are two bile acid-activated receptors that exert regulatory effects on lipid, glucose, energy, and immune homeostasis. GPBAR1 and FXR ligands have shown efficacy in reversing steatohepatitis and fibrosis in preclinical models of NASH. |
| 靶点 | FXR |
| 参考资料 展开查看 | Orrico M, Ronchey S, Setacci C, et al. The "Destino-guided BEVAR" to Catheterize Downward Branches from a Femoral Access: Technical Note and Case Report. Ann Vasc Surg. 2019;57:266-271. doi:10.1016/j.avsg.2018.09.044 |
Vonafexor - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.042 ml | 10.209 ml | 20.419 ml |
| 5 mM | 0.408 ml | 2.042 ml | 4.084 ml |
| 10 mM | 0.204 ml | 1.021 ml | 2.042 ml |
| 5 mM | 0.041 ml | 0.204 ml | 0.408 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: 4-氯-5-(4-((2,6-二氯苯基)磺酰基)哌嗪-1-基)苯并呋喃-2-羧酸 去供应商网站查看 询盘CAS: 1192171-69-9
产地: 上海
规格: C960699
价格: 100mg-1938,25mg-758,50mg-1212,1ml-720
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: 4-氯-5-(4-((2,6-二氯苯基)磺酰基)哌嗪-1-基)苯并呋喃-2-羧酸 去供应商网站查看 询盘CAS: 1192171-69-9
产地: 上海
规格: C960699
价格: 100mg-1938,25mg-758,50mg-1212,1ml-720
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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