YP001
4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid
CAS: 1192171-69-9
Molecular Formula: C19H15Cl3N2O5S
YP001 - Names and Identifiers
YP001 - Physico-chemical Properties
| Molecular Formula | C19H15Cl3N2O5S |
| Molar Mass | 489.76 |
| Density | 1.604±0.06 g/cm3(Predicted) |
| Boling Point | 680.5±65.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 3.05±0.30(Predicted) |
| Storage Condition | -20℃ |
| Use | Vonafexor, also known as EYP001, is a farnesoid X receptor agonist. Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) for which therapy is suboptimal. The farnesoid-X-receptor (FXR) and the G protein bile acid receptor (GPBAR)1 are two bile acid-activated receptors that exert regulatory effects on lipid, glucose, energy, and immune homeostasis. GPBAR1 and FXR ligands have shown efficacy in reversing steatohepatitis and fibrosis in preclinical models of NASH. |
| Target | FXR |
YP001 - Reference
| Reference Show more | Orrico M, Ronchey S, Setacci C, et al. The "Destino-guided BEVAR" to Catheterize Downward Branches from a Femoral Access: Technical Note and Case Report. Ann Vasc Surg. 2019;57:266-271. doi:10.1016/j.avsg.2018.09.044 |
YP001 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.042 ml | 10.209 ml | 20.419 ml |
| 5 mM | 0.408 ml | 2.042 ml | 4.084 ml |
| 10 mM | 0.204 ml | 1.021 ml | 2.042 ml |
| 5 mM | 0.041 ml | 0.204 ml | 0.408 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 4-chloro-5-[4-(2,6-dichlorobenzene-1- sulfonyl)piperazin-1-yl]-1-benzofuran-2-carboxylic acid Visit Supplier Webpage Request for quotation
CAS: 1192171-69-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1192171-69-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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