中文名 | Y-27632 |
英文名 | Y-27632 |
别名 | Y-27632二盐酸盐 ROCK-I和ROCK-II抑制剂 ROCK抑制剂(AZAINDOLE1) ROCK-I和ROCK-II抑制剂(Y-27632) 反式-4-(R-1-氨基乙基)-N-(吡啶-4-基)环己烷甲酰胺 4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)环己烷-1-甲酰胺 4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)环己烷-1-甲酰胺二盐酸盐 |
英文别名 | Y-27632 Y-276322HCl ROCK INHIBITOR Y-27632 DIHYDROCHLORIDE (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE |
CAS | 146986-50-7 |
EINECS | 1312995-182-4 |
化学式 | C14H21N3O |
分子量 | 247.34 |
密度 | 1.136±0.06 g/cm3(Predicted) |
熔点 | >260°C (dec.) |
沸点 | 462.6±15.0 °C(Predicted) |
溶解度 | H2O: 14 mg/mL |
酸度系数 | 13.53±0.40(Predicted) |
存储条件 | Keep in dark place,Sealed in dry,2-8°C |
稳定性 | 吸湿性 |
外观 | 固体 |
颜色 | white |
体外研究 | Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group. |
体内研究 | Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group). |
危险品标志 | Xn - 有害物品 |
风险术语 | 20/21/22 - 吸入、皮肤接触及吞食有害。 |
安全术语 | 36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
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