Y-27632
Y-27632
CAS: 146986-50-7
Molecular Formula: C14H21N3O
Y-27632 - Names and Identifiers
Y-27632 - Physico-chemical Properties
| Molecular Formula | C14H21N3O |
| Molar Mass | 247.34 |
| Density | 1.136±0.06 g/cm3(Predicted) |
| Melting Point | >260°C (dec.) |
| Boling Point | 462.6±15.0 °C(Predicted) |
| Solubility | DMSO:50 mg/mL |
| Appearance | solid |
| Color | white |
| pKa | 13.53±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Stability | Hygroscopic |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group. |
| In vivo study | Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group). |
Y-27632 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
Y-27632 - Introduction
Y-27632 is a competitive ROCK-I and ROCK-II inhibitor of ATP, which Y-27632 induce human induced pluripotent stem cells (hIPSCs) to selectively differentiate into mesenchymal lineages through epithelial-mesenchymal transition-like regulation.
Last Update：2022-10-16 17:41:24
Y-27632 - Reference Information
| biological activity | Y-27632 are orally effective, ATP competitive ROCK-I and ROCK-II inhibitors, Ki is 220 nM and 300 nM respectively. Y-27632 induces apoptosis (apoptosis). Y-27632 human induced pluripotent stem cells (hIPSCs) selectively differentiate into mesenchymal lineages through epithelial-mesenchymal transition-like regulation. |
Last Update：2024-04-09 21:54:55
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Product Name: Y-27632 Visit Supplier Webpage Request for quotationCAS: 146986-50-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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