中文名 | Bullatine G |
英文名 | Bullatine G |
别名 | 华北乌头碱 准葛尔乌头碱 准噶尔乌头碱 准格尔乌头碱 雪上一枝蒿 G 宋果灵(准格尔乌头碱) |
英文别名 | Xuan-Wu 2 songorine Zongorine Napellonin Bullatine G Napellonine ShiMoburo base I Songorine,BullatineG (20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one (3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one |
CAS | 509-24-0 |
EINECS | 200-158-5 |
化学式 | C22H31NO3 |
分子量 | 357.49 |
密度 | 1.29 |
熔点 | 201-203℃ |
沸点 | 535.8±50.0 °C(Predicted) |
比旋光度 | D20 -135.4° |
闪点 | 277.8℃ |
酸度系数 | 14.20±0.60(Predicted) |
存储条件 | 2-8°C |
物化性质 | 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于川乌,乌头。 |
体内研究 | Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorineinhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax. Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD 50 and ED 50 values of 142 mg and 7.3mg, respectively. |
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