四氢生物喋呤_化工百科

中文名	Tetrahydrobiopterin
英文名	Tetrahydrobiopterin
别名	四氢生物喋呤化合物 T17056 (6R,S)-5,6,7,8-四氢-L-生物蝶呤二盐酸盐
英文别名	bh4 6R-BH4 THB, 2HCL (6R)-BH4 2HCL Tetrahydrobiopterin TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinon 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinone [6R-[6R(1R,2S*)]]-2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE DIHYDROCHLORIDE
CAS	17528-72-2
化学式	C9H15N5O3
分子量	241.25
密度	1.89±0.1 g/cm3(Predicted)
熔点	>202°C (dec.)
沸点	506.6±60.0 °C(Predicted)
溶解度	酸水溶液 (微溶) 、DMSO (微溶) 、水 (微溶)
酸度系数	14.22±0.20(Predicted)
存储条件	-20°C
稳定性	吸湿性
外观	固体
颜色	White to Off-White
体外研究	MicMicroglial cell cultures under hyperoxia are supplemented or not with an effective dose of Tetrahydrobiopterin (BH4) (100 μM). Exposure of microglial cells to hyperoxia-induced oxidative stress for 24 h reveals a robust increase in TSP-1 mRNA expression and protein compare to normoxia (21% O 2 ). Tetrahydrobiopterin supplementation significantly prevents hyperoxia-induced microglial activation by diminishing Iba-1 and TSP-1 expression and prevents microvascular injury in choroidal explants.
体内研究	To assess the levels of Tetrahydrobiopterin in the retina, three to five pools of retinas are collected from WT and hph-1mice at postnatal age 7, 14, and 22 and evaluated by LC-MS/MS. LC-MS/MS analysis confirm a significant decrease by approximately 90% in the concentration levels of Tetrahydrobiopterin in retinal tissue from hph-1 mice (0.0009±0.0006; p<0.0001, 0.01±0.001; p<0.0001 and 2.45±0.40; p<0.005) compare to the WT group (0.014±0.001, 0.092±0.01, and 23.13±6.44) at P7, P14, and P22, respectively.
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。
参考资料展开查看	1. [IF=5.81] Yan Tao et al."Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH4/eNOS to Improve Intestinal Ischemia."Front Pharmacol. 2021 Apr;0:893

四氢生物喋呤 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.183 ml	15.915 ml	31.83 ml
5 mM	0.637 ml	3.183 ml	6.366 ml
10 mM	0.318 ml	1.592 ml	3.183 ml
5 mM	0.064 ml	0.318 ml	0.637 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: Tetrahydrobiopterin 去供应商网站查看询盘
CAS: 17528-72-2
产地: 中国上海
包装: 10mg
规格: 98%
价格: 1718.00
库存: 7个工作日
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产品描述: 中文名：Tetrahydrobiopterin 英文名:Tetrahydrobiopterin CAS:17528-72-2 规格:98% 产地:中国上海

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产品名: Tetrahydrobiopterin 去供应商网站查看询盘
CAS: 17528-72-2
产地: 上海
规格: T881370
价格: 5mg-1342,10mg-2148
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上海源叶生物科技有限公司

现货供应

产品名: Tetrahydrobiopterin 去供应商网站查看询盘
CAS: 17528-72-2
产地: 上海
规格: 98%
价格: 5mg 1200,10mg 1900,50mg 6700
库存: 现货
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