中文名 | 毛蕊异黄酮苷 |
英文名 | calycosin-7-o-beta-d-glucoside |
别名 | 毛蕊异黄酮苷 毛蕊异黄酮葡萄糖苷 毛蕊异黄酮苷(标准品) 毛蕊异黄酮-7-O-葡萄糖苷 毛蕊异黄酮-7-O-Β-D葡萄糖苷 毛蕊异黄酮-7-O-B-D-吡喃葡萄糖 毛蕊异黄酮-7-O-BETA-D-葡萄糖苷 |
英文别名 | CS-2023 CALYCOSIN 7-O-GLUCOSIDE Calycosin 7-O-Glucoside calycosin-o-glucopyranoside calycosin-7-O-β-D-glucoside Calycosin-7-O-beta-D-glucoside calycosin-7-o-beta-d-glucoside Calycosin-7-glucoside 20633-67-4 Calycosin-7-O-b-D-glucopyranoside 3',7-Dihydroxy-4'-Methoxyisoflavone-7-beta-D-glucopyranoside 3-(3-Hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside 4H-1-benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)- |
CAS | 20633-67-4 |
化学式 | C22H22O10 |
分子量 | 446.41 |
InChI | InChI=1/C22H22O10/c1-29-15-5-2-10(6-14(15)24)13-9-30-16-7-11(3-4-12(16)18(13)25)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7,9,17,19-24,26-28H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1 |
密度 | 1.545 |
熔点 | 220 - 228°C |
沸点 | 745.2±60.0 °C(Predicted) |
闪点 | 262°C |
蒸汽压 | 2.51E-23mmHg at 25°C |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
折射率 | 1.674 |
酸度系数 | 9.48±0.10(Predicted) |
存储条件 | Inert atmosphere,Room Temperature |
外观 | 固体 |
颜色 | Pale Beige |
物化性质 | 白色结晶粉末,溶于甲醇乙醇,来源于黄芪根茎。 |
MDL号 | MFCD08061493 |
体外研究 | Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex. |
体内研究 | Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model. Animal Model: Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats Dosage: 26.8 mg/kg Administration: Intraperitoneal injection; 26.8 mg/kg; 14 days Result: Exhibited neuroprotective effects in rats. |
海关编号 | 2932996560 |
上游原料 | 3-羟基-4-甲氧基苯乙酸 |
参考资料 展开查看 | 1. 黎映琼 蔡庆群 苏志强 等. 不同产地黄芪根 茎 叶中4种异黄酮类成分的比较及其聚类分析[J]. 现代中药研究与实践 2020 v.34;No.173(02):69-73. 2. 石晓倩, 何玲, 刘雪,等. 新安名方脑络欣通HPLC指纹图谱研究[J]. 辽宁中医药大学学报, 2020, v.22;No.191(03):40-44. 3. 赵晓莉, 潘鹏, 周乐,等. 毛蕊异黄酮葡萄糖苷大鼠在体肠吸收动力学的研究[J]. 南京中医药大学学报, 2012, 28(006):552-554. 4. 赵晓莉, 刘玲, 狄留庆,等. 毛蕊异黄酮葡萄糖苷对升麻素苷及其苷元大鼠体内药代动力学特征的影响研究[J]. 中国中药杂志, 2014, 39(23):4669. 5. 张星, 陆兔林, 毛春芹,等. 补阳还五汤质量标准研究[J]. 中成药, 2013, 35(003):529-533. 6. 袁菊丽, 刘东玲, 黄钰芳. 超声提取红芪总黄酮工艺及其抗氧化活性的研究[J]. 中兽医医药杂志, 2019, 038(002):53-56. 7. 田湾湾, 钟琳瑛, 张琦,等. 车前子酒炙工艺优选及其不同炮制品对比研究[J]. 天津中医药, 2020, v.37(02):106-112. 8. 刘玲, 赵晓莉, 狄留庆,等. 采用体外肠道菌群实验研究防风对黄芪中毛蕊异黄酮葡萄糖苷代谢的影响[J]. 南京中医药大学学报, 2015, 000(002):170-173. 9. 李丽, 郜玉钢, 赵丽,等. 黄芪营养生长期茎叶毛蕊异黄酮苷和黄芪甲苷含量测定[J]. 辽宁中医杂志, 2014, 041(009):1942-1944. 10. 侯美如, 尹珺伊, 王岩,等. 黄芪发酵前后黄酮含量及指纹图谱比较研究[J]. 中国兽药杂志, 2018, v.52(05):52-58. 11. 李欣, 卓冰雨, 祁晓娟,等. 黄芪异黄酮含量与气候因子的灰色关联度和通径分析[J]. 中国中药杂志 2020年45卷14期, 3407-3413页, MEDLINE ISTIC PKU CSCD CA BP, 2020. 12. 王艺璇 李海涛 刘顺 等. 参葵通脉颗粒的质量标准研究[J]. 中药新药与临床药理 2020年31卷8期 984-989页 ISTIC PKU CSCD CA 2020. 13. 田文仓. 不同生长年限及采收期子洲黄芪鉴别特征及其质量、产量差异分析[D].北京中医药大学,2020. 14. 孙乐,吴鹏,王春艳,张学兰,金玉翠,刘海滨.黄芪饮片炮制工艺优选[J].时珍国医国药,2020,31(07):1616-1619. 15. 孙秀蕊,魏桂杰,王宏雅,赵雯雯,张哲,张婷,魏锋,张玉杰.基于外观性状和内在成分的黄芪药材质量等级评价[J].中国中药杂志,2021,46(04):966-971. 16. 张丽,卞晓坤,赵秋龙,钱大玮,郭盛,严辉,欧阳臻,赵建军,段金廒.基于多元成分的黄芪药材产地现代干燥加工方法[J].中国现代中药,2020,22(10):1684-1688. 17. 毛文点,庹玲玲,齐文续,苏睿智,邓常清,邹龙.黄芪-当归不同配伍对其6种主要有效成分溶出的影响[J].湖南中医药大学学报,2021,41(03):350-354. 18. Wang, Lingdi, et al. "Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency." Evidence-Based Complementary and Alternative Medicine 2021 (2021).https://doi.org/10.1155/2021/6614302 19. Peng-Peng, L. I. U., et al. "Metabolomics analysis and rapid identification of changes in chemical ingredients in crude and processed Astragali Radix by UPLC-QTOF-MS combined with novel informatics UNIFI platform." Chinese journal of natural medicines 16.9 20. [IF=4.759] Yuping Zhang et al."On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali."J Chromatogr A. 2013 Jun;1293:92 21. [IF=4.411] Liangliang Liu et al."Rapid Screening and Identification of BSA Bound Ligands from Radix astragali Using BSA Immobilized Magnetic Nanoparticles Coupled with HPLC-MS."Molecules. 2016 Nov;21(11):1471 22. [IF=3.935] Nan Mi et al."Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: An integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical analysis."J Pharmaceut Biomed. 2019 Feb;164:70 23. [IF=3.361] Taofang Cheng et al."Hybrid multidimensional data acquisition and data processing strategy for comprehensive characterization of known, unknown and isomeric compounds from the compound Dan Zhi Tablet by UPLC-TWIMS-QTOFMS."Rsc Adv. 2019 Mar;9(16):8714-8727 24. [IF=5.81] Gu Junfei et al."Standardized Astragalus Mongholicus Bunge-Curcuma Aromatica Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice."Front Pharmacol. 2021 Aug;0:2278 25. [IF=5.34] Tao-Fang Cheng et al."Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation."Phytomedicine. 2020 Dec;79:153330 26. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 27. [IF=4.411] Liyu Luo et al."Integrated Phytochemical Analysis Based on UPLC-MS and Network Pharmacology Approaches to Explore the Quality Control Markers for the Quality Assessment of Trifolium pratense L.."Molecules. 2020 Jan;25(17):3787 28. [IF=4.225] Zhang Wei et al."Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP–Induced Injury in HSCs."Front Pharmacol. 2019 Aug;0:936 29. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 30. [IF=3.765] Shun Liu et al."Simultaneous determination of seven effective components in Shenkui Tongmai granules based on UHPLC-MS/MS."J Pharm Pharmacol. 2021 Apr;73(6):758-766 31. [IF=2.629] Wang Lingdi et al."Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency."Evid-Based Compl Alt. 2021;2021:6614302 32. [IF=1.913] Xie Qingling et al."A Rapid and Accurate 1HNMR Method for the Identification and Quantification of Major Constituents in Qishen Yiqi Dripping Pills."J Aoac Int. 2021 May;104(2):506-514 33. [IF=1.902] Jia Wang et al."Investigate the effect of honey on the absorption of seven active ingredients from wu-tou decoction in rats."Biomedical Chromatography. 2022 Jan 06 34. [IF=4.36] Yule Wang et al."Synergy of “Yiqi” and “Huoxue” components of QishenYiqi formula in ischemic stroke protection via lysosomal/inflammatory mechanisms."JOURNAL OF ETHNOPHARMACOLOGY. 2022 Jul;293:115301 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!