毛蕊花糖苷
毛蕊花糖苷(acteoside)
CAS: 61276-17-3
化学式: C29H36O15
| 中文名 | 毛蕊花糖苷 |
| 英文名 | acteoside |
| 别名 | 阿克苷 麦角甾苷 毛蕊花苷 毛蕊花糖苷 类叶升麻苷 麦角甾苷(毛蕊花糖苷) 麦角甾苷, 来源于肉苁蓉 类叶升麻苷,毛蕊花糖苷(标准品) 毛蕊花糖苷(麦角甾苷,阿克苷,类叶升麻苷) |
| 英文别名 | Acetoside acteoside verbascoside Verbascoside VERBASCOSIDE WITH HPLC 3,4-Dihydroxyphenethyl alcohol acteoside Extract from Verbena minutiflora (B864379) glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxyhexopyranosyl)-4-O-[3-(3,4-dihydroxyphenyl)acryloyl]hexopyranoside 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate] 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| CAS | 61276-17-3 |
| 化学式 | C29H36O15 |
| 分子量 | 624.59 |
| InChI | InChI=1/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1 |
| InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N |
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 熔点 | 232℃ |
| 沸点 | 908.8±65.0 °C(Predicted) |
| 比旋光度 | (c, 1.15 in MeOH)-84.9 |
| 闪点 | 294.7°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (微溶)，乙酸乙酯 (非常微溶)，甲醇 (微溶) |
| 折射率 | 1.689 |
| 酸度系数 | 9.31±0.10(Predicted) |
| 存储条件 | Sealed in dry,Room Temperature |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Pale Yellow |
| 物化性质 | 类白色或淡黄色结晶粉末，溶于甲醇，来源于大芸（硬质肉苁蓉发黑含量最高0.47%）大叶紫珠、车前子、地黄、肉苁蓉、紫竹叶。 |
| MDL号 | MFCD00221751 |
| 体外研究 | Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 µM. Verbascoside shows K i s of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells. |
| 体内研究 | Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3. |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 2 |
| RTECS | LZ5786000 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 李许 何然 王红玉 等. 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Chen, Xue, et al. "Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats." Biomedicine & Pharmacotherapy 132 (2020): 110765.https://doi.org/10.1016/j.biopha.2020.110 21. Liao, Xiaoyan, Yuan Hong, and Zilin Chen. "Identification and quantification of the bioactive components in Osmanthus fragrans roots by HPLC-MS/MS." Journal of pharmaceutical analysis 11.3 (2021): 299-307.https://doi.org/10.1016/j.jpha.2020.06.010 22. Deng, Junlin, et al. "Comparative evaluation of maceration and ultrasonic-assisted extraction of phenolic compounds from fresh olives." Ultrasonics Sonochemistry 37 (2017): 328-334.https://doi.org/10.1016/j.ultsonch.2017.01.023 23. Deng, Rui, et al. "Identification of poliumoside metabolites in rat feces by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry." 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毛蕊花糖苷 - 简介
毛蕊花糖苷是一种天然的糖苷类物质，它存在于某些植物中，主要由葡萄糖和毛蕊花苷醇组成。以下是关于毛蕊花糖苷的性质、用途、制法和安全信息的介绍：
性质：
毛蕊花糖苷是无色或微黄色结晶粉末，具有甜味。它在水中溶解度相对较高，但在酒精中的溶解度较低。这种物质在空气中相对稳定，但在酸性条件下可分解。
用途： 它的甜度大约是蔗糖的300倍，用量较少，对身体的热量负担也相对较低。
制法：
毛蕊花糖苷的制取通常通过从毛蕊花等植物中提取，并经过精细的分离和纯化步骤得到。整个制备过程中，需要采用一些化学和物理技术手段来提高产率和纯度。
安全信息： 它不被身体消化吸收，在人体内几乎不会产生代谢产物。一般情况下，毛蕊花糖苷不会引起过敏反应或其他严重不良反应。但对于少数人可能存在对该物质过敏的情况，在使用过程中应注意个体差异。
性质：
毛蕊花糖苷是无色或微黄色结晶粉末，具有甜味。它在水中溶解度相对较高，但在酒精中的溶解度较低。这种物质在空气中相对稳定，但在酸性条件下可分解。
用途： 它的甜度大约是蔗糖的300倍，用量较少，对身体的热量负担也相对较低。
制法：
毛蕊花糖苷的制取通常通过从毛蕊花等植物中提取，并经过精细的分离和纯化步骤得到。整个制备过程中，需要采用一些化学和物理技术手段来提高产率和纯度。
安全信息： 它不被身体消化吸收，在人体内几乎不会产生代谢产物。一般情况下，毛蕊花糖苷不会引起过敏反应或其他严重不良反应。但对于少数人可能存在对该物质过敏的情况，在使用过程中应注意个体差异。
最后更新：2024-04-09 20:49:11
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产品名: 类叶升麻苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IV00501
产地: 北京
包装: 1ml/瓶
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库存: 现询
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Verbascoside 去供应商网站查看 询盘CAS: 61276-17-3
产地: 美国
包装: 5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-N0021R
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产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
提供多种规格现货供应
产品名: 类叶升麻苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IV00501
产地: 北京
包装: 1ml/瓶
规格: IV00501-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Verbascoside 去供应商网站查看 询盘CAS: 61276-17-3
产地: 美国
包装: 5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-N0021R
库存: 询盘
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
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