类叶升麻苷
毛蕊花糖苷(acteoside)
CAS: 61276-17-3
化学式: C29H36O15
| 中文名 | 毛蕊花糖苷 |
| 英文名 | acteoside |
| 别名 | 阿克苷 麦角甾苷 毛蕊花苷 毛蕊花糖苷 类叶升麻苷 麦角甾苷(毛蕊花糖苷) 麦角甾苷, 来源于肉苁蓉 类叶升麻苷,毛蕊花糖苷(标准品) 毛蕊花糖苷(麦角甾苷,阿克苷,类叶升麻苷) |
| 英文别名 | Acetoside acteoside verbascoside Verbascoside VERBASCOSIDE WITH HPLC 3,4-Dihydroxyphenethyl alcohol acteoside Extract from Verbena minutiflora (B864379) glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxyhexopyranosyl)-4-O-[3-(3,4-dihydroxyphenyl)acryloyl]hexopyranoside 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate] 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| CAS | 61276-17-3 |
| 化学式 | C29H36O15 |
| 分子量 | 624.59 |
| InChI | InChI=1/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1 |
| InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N |
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 熔点 | 232℃ |
| 沸点 | 908.8±65.0 °C(Predicted) |
| 比旋光度 | (c, 1.15 in MeOH)-84.9 |
| 闪点 | 294.7°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (微溶)，乙酸乙酯 (非常微溶)，甲醇 (微溶) |
| 折射率 | 1.689 |
| 酸度系数 | 9.31±0.10(Predicted) |
| 存储条件 | Sealed in dry,Room Temperature |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Pale Yellow |
| 物化性质 | 类白色或淡黄色结晶粉末，溶于甲醇，来源于大芸（硬质肉苁蓉发黑含量最高0.47%）大叶紫珠、车前子、地黄、肉苁蓉、紫竹叶。 |
| MDL号 | MFCD00221751 |
| 体外研究 | Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 µM. Verbascoside shows K i s of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells. |
| 体内研究 | Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3. |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 2 |
| RTECS | LZ5786000 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 李许 何然 王红玉 等. D-半乳糖致衰老大鼠脑内促红细胞生成素表达下调及熟地黄的逆转作用[J]. 中国药学杂志 2016 051(018):1562-1568. 2. 李婷 许霞 常安琪 刘文静 宋青青 宋月林 屠鹏飞.利用在线加压溶剂提取-超高效液相色谱-离子肼-飞行时间-质谱法直接分析中药草苁蓉的化学成分组[J].色谱 2020 38(05):554-563. 3. 杨德亮,徐凤,刘秀,张闯,吴明根.地黄耐百草枯的有效成分分析[J].江苏农业科学,2014,42(01):100-102. 4. 奚亚亚, 刁家葳, 张学兰,等. 女贞子中4种成分在大鼠血浆中的药动学行为[J]. 中成药, 2018, v.40(08):59-64. 5. 徐保鑫, 李转梅, 张学兰,等. 女贞子中橄榄苦苷与羟基酪醇在大鼠血浆中的药动学差异[J]. 中成药, 2017, 39(007):1387-1390. 6. 于福来, 吴丽芬, 庞玉新,等. 海南裸花紫珠中毛蕊花糖苷和木犀草苷含量分析[J]. 中国现代中药, 2016, 18(008):996-1000. 7. 丁艳霞,王晓琴,张英.基于高效液相色谱的肉苁蓉属药材6个主要苯乙醇苷类成分的含量测定[J].时珍国医国药,2020,31(04):813-816. 8. 陆春红, 许惠琴, 刘凯,等. 生地环烯醚萜苷类成分对AGEs损伤HUVEC的保护作用[J]. 南京中医药大学学报, 2015, 31(001):55-59. 9. 蒙雄裕, 徐良, 李华强,等. 用RP-HPLC法测定天目地黄中梓醇和毛蕊花糖苷的含量[J]. 药学服务与研究, 2015, 15(004):273-276. 10. 田湾湾, 钟琳瑛, 张琦,等. 车前子酒炙工艺优选及其不同炮制品对比研究[J]. 天津中医药, 2020, v.37(02):106-112. 11. 刘鑫, 赫一鸣, 蔡广知,等. 多指标综合评分优选炒车前子工艺研究[J]. 辽宁中医药大学学报, 2018, 020(010):78-81. 12. 姜秋, 蒋海强, 李慧芬,等. 女贞子酒蒸过程中5种苯乙醇类成分的变化规律[J]. 中国实验方剂学杂志, 2014, 20(16):60-63. 13. 谭湘杰, 于福来, 庞玉新,等. 海南裸花紫珠药材中7种成分含量分析[J]. 中国现代中药, 2018, 20(002):173-178. 14. 黄梅, 于福来, 陈振夏,等. 土壤因子对裸花紫珠有效成分含量的影响研究[J]. 中国药房, 2018(1):2095-2099. 15. 任永申, 邓鑫, 雷蕾,等. 基于抑菌效应成分指纹谱的黄芩质量评价研究[J]. 药学学报, 2019, 054(012):2155-2161. 16. 陶玉菡,许惠琴,李莉,农伟虎,李伟.生地、山茱萸抑制和清除糖基化产物的效应成分研究[J].中药药理与临床,2013,29(04):30-33. 17. 宋晓芳 范宝磊 曾祥玲 李婷婷 史玉敏 邹晶晶 杨洁 陈洪国.HPLC-MS/MS法同时测定不同桂花品种中7个多酚类活性成分的含量[J].药物分析杂志 2019 39(10):1811-1820. 18. 朱晓富,邓才富,潭秋生,杨丹,卢圣鄂,任风鸣.渝产玄参不同“发汗”天数质量评价[J].中药与临床,2020,11(05):8-10. 19. 余娜,唐林,谢壮鑫,周厚元,唐皓,李顺祥,朱克俭.臭牡丹不同提取物的抗肿瘤活性筛选及其对裸鼠移植瘤中EMT相关蛋白的影响[J].中药药理与临床,2020,36(04):124-131. 20. Chen, Xue, et al. "Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats." Biomedicine & Pharmacotherapy 132 (2020): 110765.https://doi.org/10.1016/j.biopha.2020.110 21. Liao, Xiaoyan, Yuan Hong, and Zilin Chen. "Identification and quantification of the bioactive components in Osmanthus fragrans roots by HPLC-MS/MS." Journal of pharmaceutical analysis 11.3 (2021): 299-307.https://doi.org/10.1016/j.jpha.2020.06.010 22. Deng, Junlin, et al. "Comparative evaluation of maceration and ultrasonic-assisted extraction of phenolic compounds from fresh olives." Ultrasonics Sonochemistry 37 (2017): 328-334.https://doi.org/10.1016/j.ultsonch.2017.01.023 23. Deng, Rui, et al. "Identification of poliumoside metabolites in rat feces by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry." Journal of Chromatography B 969 (2014): 285-296.https://doi.org/10.1016/j. 24. Yang, Ruocong, et al. "Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): in silico and experimental study." Pharmacological research 157 (2020): 104820.h 25. Wang, Wei, Dan-Dan Tian, and Zhang-Jin Zhang. "In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism." Molecules 21.5 (2016): 597.https://doi.org/10.3390/molecules21050597 26. [IF=6.023] Maiquan Li et al."Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway."Food Chem Toxicol. 2018 Sep;119:6 27. [IF=5.279] Yirong Jiang et al."Phenylethanoid Glycoside Profiles and Antioxidant Activities of Osmanthus fragrans Lour. Flowers by UPLC/PDA/MS and Simulated Digestion Model."J Agr Food Chem. 2016;64(12):2459–2466 28. [IF=5.279] Xiaoyan Liao et al."Identification and Quantitation of the Bioactive Components in Osmanthus fragrans Fruits by HPLC-ESI-MS/MS."J Agr Food Chem. 2018;66(1):359–367 29. [IF=4.556] Maiquan Li et al."Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway."Int J Mol Sci. 2018 Apr;19(4):1135 30. [IF=4.411] Wei Wang et al."In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism."Molecules. 2016 May;21(5):597 31. [IF=4.411] Dan-Dan Tian et al."Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats."Molecules. 2016 Jun;21(6):696 32. [IF=3.205] Rui Deng et al."Identification of poliumoside metabolites in rat feces by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry."J Chromatogr B. 2014 Oct;969:285 33. [IF=2.629] Zhang Ying et al."The Difference of Chemical Components and Biological Activities of the Raw Products slices and the Wine Steam-Processed Product from Cistanche deserticola."Evid-Based Compl Alt. 2019;2019:2167947 34. [IF=6.986] Qingqing Song et al."Retention Time and Optimal Collision Energy Advance Structural Annotation Relied on LC–MS/MS: An Application in Metabolite Identification of an Antidementia Agent Namely Echinacoside."Anal Chem. 2019;91(23):15040–15048 35. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 36. [IF=6.529] Xue Chen et al."Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats."Biomed Pharmacother. 2020 Dec;132:110765 37. [IF=5.893] Ruocong Yang et al."Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study."Pharmacol Res. 2020 Jul;157:104820 38. [IF=5.455] Zhang Xian et al."Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine."Chin Med-Uk. 2021 Dec;16(1):1-19 39. [IF=4.769] Xiaoyan Liao et al."Identification and quantification of the bioactive components in Osmanthus fragrans roots by HPLC-MS/MS."J Pharm Anal. 2021 Jun;11:299 40. [IF=4.36] Chenglin Song et al."Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis."J Ethnopharmacol. 2021 Dec;281:114571 41. [IF=4.183] Wan Gong et al."Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats."Int J Mol Sci. 2019 Jan;20(16 42. [IF=4.142] Lei Huibo et al."Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular ne 43. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 44. [IF=3.935] Yong-Sheng Wu et al."Chemical profiling of Callicarpa nudiflora and its effective compounds identification by compound-target network analysis."J Pharmaceut Biomed. 2020 Apr;182:113110 45. [IF=3.69] Qixin Wang et al."Phenylethanol glycosides from Cistanche tubulosa improved reproductive dysfunction by regulating testicular steroids through CYP450-3β-HSD pathway."J Ethnopharmacol. 2020 Apr;251:112500 46. [IF=3.279] Pengfei Yuan et al."Cistanche tubulosa Phenylethanoid Glycosides Induce Apoptosis of Hepatocellular Carcinoma Cells by Mitochondria-Dependent and MAPK Pathways and Enhance Antitumor Effect through Combination with Cisplatin:."Integr Cancer Ther. 2021;(): 47. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153 48. [IF=3.645] Shuo Gu et al."Develop a stepwise integrated method to screen biomarkers of Baihe-Dihuang Tang on the treatment of depression in rats applying with composition screened, untargeted, and targeted metabolomics analysis."Journal Of Separation Science. 2022 M 49. [IF=4.508] Chunying Li et al."A novel approach for echinacoside and acteoside extraction from Cistanche deserticola Y. C. Ma using an aqueous system containing ionic liquid surfactants."Sustain Chem Pharm. 2022 May;26:100644 50. [IF=1.134] Ting-Ting ZHANG et al."Construction of ERGO film modified electrode and its combination with HPLC in determination of five active components in Osmanthus fragrans fruits."CHINESE JOURNAL OF ANALYTICAL CHEMISTRY. 2022 Jul;50:100109 |
类叶升麻苷 - 简介
毛蕊花糖苷是一种天然的糖苷类物质，它存在于某些植物中，主要由葡萄糖和毛蕊花苷醇组成。以下是关于毛蕊花糖苷的性质、用途、制法和安全信息的介绍：
性质：
毛蕊花糖苷是无色或微黄色结晶粉末，具有甜味。它在水中溶解度相对较高，但在酒精中的溶解度较低。这种物质在空气中相对稳定，但在酸性条件下可分解。
用途： 它的甜度大约是蔗糖的300倍，用量较少，对身体的热量负担也相对较低。
制法：
毛蕊花糖苷的制取通常通过从毛蕊花等植物中提取，并经过精细的分离和纯化步骤得到。整个制备过程中，需要采用一些化学和物理技术手段来提高产率和纯度。
安全信息： 它不被身体消化吸收，在人体内几乎不会产生代谢产物。一般情况下，毛蕊花糖苷不会引起过敏反应或其他严重不良反应。但对于少数人可能存在对该物质过敏的情况，在使用过程中应注意个体差异。
性质：
毛蕊花糖苷是无色或微黄色结晶粉末，具有甜味。它在水中溶解度相对较高，但在酒精中的溶解度较低。这种物质在空气中相对稳定，但在酸性条件下可分解。
用途： 它的甜度大约是蔗糖的300倍，用量较少，对身体的热量负担也相对较低。
制法：
毛蕊花糖苷的制取通常通过从毛蕊花等植物中提取，并经过精细的分离和纯化步骤得到。整个制备过程中，需要采用一些化学和物理技术手段来提高产率和纯度。
安全信息： 它不被身体消化吸收，在人体内几乎不会产生代谢产物。一般情况下，毛蕊花糖苷不会引起过敏反应或其他严重不良反应。但对于少数人可能存在对该物质过敏的情况，在使用过程中应注意个体差异。
最后更新：2024-04-09 20:49:11
供应商列表
提供多种规格现货供应
产品名: 类叶升麻苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IV00501
产地: 北京
包装: 1ml/瓶
规格: IV00501-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
提供多种规格现货供应
产品名: 类叶升麻苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IV00501
产地: 北京
包装: 1ml/瓶
规格: IV00501-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！