汉黄芩苷
汉黄芩苷(5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid)
CAS: 51059-44-0
化学式: C22H20O11
| 中文名 | 汉黄芩苷 |
| 英文名 | 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid |
| 别名 | 汉黄芩苷 汉黄岑苷 汉黄芩苷(标准品) 汉黄芩苷(汉黄芩甙) WOGONOSIDE 汉黄芩苷 汉黄芩素-7-O-葡萄糖醛酸苷 汉黄芩苷(汉黄芩素-7-O-葡萄糖醛酸苷 汉黄芩苷(汉黄芩素-7-O-葡萄糖醛酸苷,汉黄芩甙) |
| 英文别名 | WOGONOSIDE wogonoside B-D-GLUCOPYRANOSIDURONICACID wogonin 7-O-beta-D-glucuronide Beta-D-Glucopyranosiduronic Acid BETA-D-GLUCOPYRANOSIDURONIC ACID β-D-Glucopyranosiduronic acid,5-hydroxy- 8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid |
| CAS | 51059-44-0 |
| 化学式 | C22H20O11 |
| 分子量 | 460.39 |
| InChI | InChI=1/C22H20O11/c1-30-18-13(32-22-17(27)15(25)16(26)20(33-22)21(28)29)8-11(24)14-10(23)7-12(31-19(14)18)9-5-3-2-4-6-9/h2-8,15-17,20,22,24-27H,1H3,(H,28,29)/t15-,16-,17+,20-,22+/m0/s1 |
| InChIKey | LNOHXHDWGCMVCO-NTKSAMNMSA-N |
| 密度 | 1.629 |
| 熔点 | 226-227℃ |
| 沸点 | 820.7±65.0 °C(Predicted) |
| 闪点 | 288.6°C |
| 蒸汽压 | 1.66E-28mmHg at 25°C |
| 溶解度 | DMSO (微溶)，甲醇 (非常微溶) |
| 折射率 | 1.693 |
| 酸度系数 | 2.73±0.70(Predicted) |
| 存储条件 | -20°C |
| 敏感性 | Sensitive to light |
| 外观 | 固体 |
| 颜色 | Pale Yellow |
| 物化性质 | 黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于黄芩。 |
| MDL号 | MFCD08704808 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1. 曾燕, 郭兰萍, 王继永,等. 基于电子舌技术的不同来源黄芩药材味觉信息分析及味觉信息与主要化学成分的相关性研究[J]. 中国现代中药, 2015, 17(011):1139-1147 2. 王晓东. 汉黄芩素对人肝癌SMMC-7721的抑制作用及其作用机制研究[J]. 中国继续医学教育, 2016(34). 3. 李文媛, 宋丽华. 汉黄芩苷体外抗结肠癌作用及机制研究[J]. 中国药物与临床, 2017(8). 4. 陈阳, 崔波, 范燕豪,等. 葛根芩连汤中各成分在正常与大肠湿热证模型大鼠的肠吸收差异研究[J]. 中国中药杂志, 2020, v.45(01):177-186. 5. 李云静 张建逵 王冰 等. 不同产地黄芩药材中黄芩苷等5种黄酮类成分含量的比较[J]. 时珍国医国药 2016 027(012):2985-2988. 6. 王东超 魏颖 高佳琪 孙文 秦灵灵 兰卫 石浩霞 李博 徐暾海 刘铜华.HPLC同时测定糖痹康颗粒中黄芩苷、汉黄芩苷、黄芩素、汉黄芩素的含量[J].吉林中医药 2017 37(05):513-517. 7. 李淑娇, 王宇卿. 基于HPLC-Q-TOF/MS法的黄芩血清药物化学分析[J]. 中成药, 2019, 41(03):117-122. 8. 刘媛媛, 刘陶, 吴玉梅,等. 基于雌激素受体调节Nrf2-ARE通路的黄芩中抗氧化成分的筛选[J]. 中国药理学通报, 2019, 035(006):822-827. 9. 程燕, 曲绍风, 李福伟,等. 黄芩中4种黄酮类化合物的亚临界水提取研究[J]. 山东科学, 2013(03):11-14. 10. 王子凌云 梁琨 李国文. HPLC法测定芩杏清热止咳颗粒中8种成分[J]. 中成药 2019 041(005):995-999. 11. 柴冲冲 毛民 袁金凤 等. 不同方法软化切制后的黄芩饮片颜色与5种黄酮类成分含量的相关性研究[J]. 中国中药杂志 2019. 12. 柴冲冲,曹妍,毛民,王靖越,刘娜,李欣欣,张凯,陈东玲,魏龙吟,尹怡慧,李飞.基于电子舌技术评价黄芩酒炙前后滋味变化及其在黄芩饮片鉴别中的应用研究[J].中国中药杂志,2020,45(11):2552-2559. 13. 袁杰, 李锬, 周利,等. 基于超高效液相色谱法和色差仪法的黄芩药材质量评价[J]. 世界中医药, 2019. 14. 李云静, 张建逵, 赵玥,等. 黄芩药材颜色及其有效成分的相关性[J]. 中国医药工业杂志, 2017(7). 15. 任永申, 邓鑫, 雷蕾,等. 基于抑菌效应成分指纹谱的黄芩质量评价研究[J]. 药学学报, 2019, 054(012):2155-2161. 16. 张静 李壮壮 杜宝香 等. HPLC法同时测定柴胡桂枝汤中6种成分[J]. 中成药 2018 040(010):2202-2205. 17. 张慧, 李思雨, 冯宏玲,等. 基于效应成分指数的双黄连制剂质量控制研究[J]. 药学学报, 2019, 054(012):2149-2154. 18. 杨梦玲, 尤朋涛, 何丽珊,等. 基于UPLC-MS/MS分析胃溃疡模型大鼠口服加味小柴胡颗粒后血浆中8种有效成分的药代动力学[J]. 中国中药杂志, 2018, 43(18). 19. 陈智. 金银花和黄芩不同煎煮方式化学成分变化及抗病毒作用比较[J]. 中华中医药杂志, 2019, v.34(10):129-133. 20. 李壮壮, 张静, 赵绍哲,等. 指纹图谱与化学计量学结合优选柴胡桂枝颗粒水提工艺[J]. 中成药, 2018, v.40(08):199-203. 21. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750. 22. Sun, Chenglong, et al. "A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi." Journal of pharmaceutical and biomedical analysis 179 (2020): 113014.https://doi.org/10.1016/j.jpba.2019.11 23. Cheng, Yan, et al. "Controlled Extraction of Flavonoids From Radix Scutellariae by Subcritical Water." CLEAN–Soil, Air, Water 44.3 (2016): 299-303.https://doi.org/10.1002/clen.201300193 24. Yu, Yunru, et al. "Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases." Chinese medicine 16.1 (2021): 1-14. 25. Wang, Qian, et al. "Identification and pharmacokinetics of multiple constituents in rat plasma after oral administration of Yinchenzhufu decoction." Journal of ethnopharmacology 153.3 (2014): 714-724.https://doi.org/10.1016/j.jep.2014.03.039 26. Xu, Jun. "Improved approaches and strategies for analyzing decoctions of medicinal herbs." (2016). 27. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https:// 28. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239 29. [IF=3.935] Liangmian Chen et al."Simultaneous determination of various bioactive redox components in Shuang–Huang–Lian preparations using a novel three-channel isocratic elution liquid chromatography with electrochemical detection system."J Pharmaceut Biomed. 2014 J 30. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 31. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15 32. [IF=1.902] Zilingyun Wang et al."Validation of an LC–MS/MS method for simultaneous detection of diverse components of Qinxing Qingre Zhike Granule in rat plasma and its application to pharmacokinetic study after oral administration to rats."Biomed Chromatogr. 2019 J 33. [IF=5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway."Front Pharmacol. 2021 Jun;0:1369 34. [IF=5.455] Yu Yunru et al."Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases."Chin Med-Uk. 2021 Dec;16(1):1-14 35. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 36. [IF=4.36] Wei Zheng et al."Inhibitory effects of Coptidis Rhizoma on the intestinal absorption and metabolism of Scutellariae Radix."J Ethnopharmacol. 2021 Apr;270:113785 37. [IF=3.935] Chenglong Sun et al."A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi."J Pharmaceut Biomed. 2020 Feb;179:113014 38. [IF=2.877] Wanli Ji et al."Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC–LTQ–Orbitrap MS."Comput Biol Chem. 2021 Aug;93:107535 39. [IF=4.36] Jiali Zhou et al.The root extract of Scutellaria baicalensis Georgi promotes β cell function and protects from apoptosis by inducing autophagy.J Ethnopharmacol. 2022 Feb;284:114790 40. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831 |
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产品名: 汉黄芩苷 紫外分光标准品 去供应商网站查看 询盘CAS: 51059-44-0
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提供多种规格
产品名: 汉黄芩苷 紫外分光标准品 去供应商网站查看 询盘CAS: 51059-44-0
产地: 北京
包装: 20mg /瓶
规格: SVW1015-20mg
价格: 电话、微信、QQ、邮件
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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