中文名 | 氯沙坦羧酸 |
英文名 | 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID |
别名 | 氯沙坦 洛沙坦杂质 氯沙坦羧酸 5-羧酸氯沙坦 5-羧酸洛沙坦 洛沙坦杂质14 洛沙坦-5-羧酸 |
英文别名 | E3174 E-3174 E 3174 EXP3174 EXP-3174 EXP 3174 AKOS 91941 E-3174, EXP-3174 LOSARTAN CARBOXY ACID '-biphenyl)-4-yl)methyl)- 1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2'-(14-tetrazol-5-yl)(1,1 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID |
CAS | 124750-92-1 |
EINECS | 1592732-453-0 |
化学式 | C22H21ClN6O2 |
分子量 | 436.89 |
密度 | 1.41±0.1 g/cm3(Predicted) |
熔点 | 130-132°C |
沸点 | 707.8±70.0 °C(Predicted) |
溶解度 | 二甲基甲酰胺、二甲基亚砜、甲醇 |
酸度系数 | 0.79±0.50(Predicted) |
存储条件 | Inert atmosphere,2-8°C |
外观 | 固体 |
颜色 | Light-Yellow |
体外研究 | The specific binding of [125I]-angiotensin II to VSMC is inhibited by Losartan Carboxylic Acid (E-3174) with an IC 50 of 1.1 nM. Losartan Carboxylic Acid abolishes the angiotensin II-induced formation of inositolphosphates in VSMC. Losartan Carboxylic Acid inhibits the angiotensin II-induced elevation of intracellular cytosolic Ca2+ concentration with an IC 50 of 5 nM. Losartan Carboxylic Acid is more effective than losartan in blocking the angiotensin II-induced increase in Egr-1 mRNA. Losartan Carboxylic Acid inhibits the angiotensin II-induced cell protein synthesis with an IC 50 of 3 nM. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
海关编号 | 29339900 |
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