中文名 | 牛磺胆酸 |
英文名 | Taurocholic Acid |
别名 | 牛膽酸 牛黄胆酸 牛磺胆酸 胺乙磺膽酸 牛磺胆酸-2,2,4,4-D4酸 N-(3α,7α,12α)三羟基-5β-胆甾烷-24-酰基牛黄酸 3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸-24-牛黄酸酰胺 N-(3ALPHA,7ALPHA,12ALPHA)三羟基-5Β-胆甾烷-24-酰基牛黄酸 |
英文别名 | taurocholate Taurocholic Acid n-choloyltaurine 3,7,12-Trihydroxy-5-cholan-24-oicacid24-taurineamide 5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL N-(2-SULPHOETHYL)-AMIDE 2-((3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholan-24-yl)amino)ethan 2-[[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]ethanesulphonic acid |
CAS | 81-24-3 |
EINECS | 201-336-2 |
化学式 | C26H45NO7S |
分子量 | 515.7 |
密度 | 1.0902 (rough estimate) |
熔点 | 125°C (rough estimate) |
比旋光度 | D18 +38.8° (c = 2 in alcohol) |
溶解度 | 易溶于水,溶于乙醇,几乎不溶于乙醚、乙酸乙酯。遇酸碱分解成胆酸和牛磺酸 |
折射率 | 1.5650 (estimate) |
酸度系数 | 1.4(at 25℃) |
存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
稳定性 | 吸湿性 |
敏感性 | Hygroscopic |
外观 | 固体 |
颜色 | White to Off-White |
物化性质 | 化学性质 非结晶形粉末。 熔点125℃(分解),[α]20/D+38.8°(乙醇-水)。易吸湿。易溶于水,溶于乙醇,几乎不溶于乙醚、乙酸乙酯。遇酸碱分解成胆酸和牛磺酸。 |
MDL号 | MFCD00053458 |
下游产品 | 去氢胆酸 |
参考资料 展开查看 | 1. 曹妍,李婷,常安琪,蒋珍珍,于娟,屠鹏飞,宋月林.蛇胆中胆汁酸类化学成分分析[J].中国中药杂志,2021,46(01):130-138. 2. Zhang, Xiaoyong, et al. "Comparative metabolomics analysis of cervicitis in human patients and a phenol mucilage-induced rat model using liquid chromatography tandem mass spectrometry." Frontiers in pharmacology 9 (2018): 282.https://doi.org/10.3389/fphar. 3. [IF=5.81] Zhang Xiaoyong et al."Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry."Front Pharmacol. 2018 Apr;0:282 4. [IF=3.935] Ziying Liu et al."Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma."J Pharmaceut Bio 5. [IF=3.361] Qingqing Song et al."Polarity-extended quantitative analysis of bear bile and its analogues using serially coupled reversed phase-hydrophilic interaction liquid chromatography-tailored multiple reaction monitoring."Rsc Adv. 2017 Nov;7(83):52822-52831 6. [IF=5.878] Min Wen et al."Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis."Phytother Res. 2021 Jul;35(7):3799-3811 7. [IF=5.34] Kaihui Zhang et al."A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis."Phytomedicine. 2021 Oct;91:153683 8. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 9. [IF=3.935] Runjing Zhang et al."Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics."J Pharmaceut Biomed. 2020 Feb;179:112966 10. [IF=5.396] Juan Wu et al."Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes."Food Funct. 2022 Feb;: 11. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 |
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