中文名 | 苯甲丁氮酮 |
英文名 | NADOLOL |
别名 | 康格多 萘羟心胺 康加尔多 纳多洛尔 苯甲丁氮酮 纳多洛尔 标准品 纳多洛尔溶液, 100PPM 2,3-顺式-1,2,3,4-四氢-5-[2-羟基-3-(叔丁氨)丙氧基]-2,3-萘二醇 |
英文别名 | NADOLOL 2,3-diol 1-(tert-butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy) 2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naph 2,3-cis-1,2,3,4-tetrahydro-5-(2-hydroxy-3-(tert-butylamino)propoxy)-2,3-naphth 1-(tert-bytylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2 1-(tert-Butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2-propanol 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol 2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- |
CAS | 42200-33-9 |
EINECS | 255-706-3 |
化学式 | C17H27NO4 |
分子量 | 309.4 |
密度 | 1.0449 (rough estimate) |
熔点 | 125-130°C |
沸点 | 449.67°C (rough estimate) |
水溶性 | 8.30g/L(25 ºC) |
溶解度 | 微溶于水,易溶于乙醇 (96%),几乎不溶于丙酮。 |
折射率 | 1.5420 (estimate) |
酸度系数 | 9.67(at 25℃) |
存储条件 | Refrigerator |
外观 | 整洁 |
颜色 | White to Off-White |
物化性质 | 结晶性粉末。熔点124-136℃,易溶于醇,微溶于氯仿,不溶于丙酮、苯。 |
体外研究 | In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a K i value of 19.4 μM. With respect to Nadolol, the K m for OATP1A2 is 84 μM. |
体内研究 | In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress. |
WGK Germany | 2 |
RTECS | QJ4870000 |
海关编号 | 2922190900 |
上游原料 | 5,8-二氢萘酚 氢氧化钠 乙酐 |
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