中文名 | 脱氧雪腐镰刀菌烯醇 |
英文名 | DEOXYNIVALENOL |
别名 | 呕吐毒素 脱氧镰刀菌烯醇 脱氧雪腐镰刀菌烯醇 脱氧瓜萎镰菌醇标准品 DON毒素,呕吐毒素 脱氧雪腐镰刀菌烯醇 溶液 3Α,7Α,15-三羟基-12,13-环氧单端孢霉-9-蒽-8-酮 |
英文别名 | DON VOMITOXIN NSC 269144 DEOXYNIVALENOL 4-Desoxynivalenol (3α,7α)-12,13-Epoxy-3,7,15-trihydroxytrichothec-9-en-8-one 3ALPHA,7ALPHA,15-TRIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE 12,13-epoxy-3,7,15-trihydroxy-,(3-alpha,7-alpha)-trichothec-9-en-8-on |
CAS | 51481-10-8 |
EINECS | 610-668-0 |
化学式 | C15H20O6 |
分子量 | 296.32 |
密度 | 1.48 |
熔点 | 151-153 C |
沸点 | 357.92°C (rough estimate) |
闪点 | -3 °C |
溶解度 | 溶于甲醇、氯仿、水 (微溶) 、乙醇 (9.8-10.2毫克/毫升) 和DMSO。 |
折射率 | 1.4359 (estimate) |
酸度系数 | 11.91±0.70(Predicted) |
存储条件 | -20°C |
稳定性 | 稳定。与强氧化剂不相容。 |
外观 | 溶液 (乙醇: 2-丙醇95:5) |
物化性质 | 化学性质 DON可与核糖体60s亚基的肽转移酶活性中心结合引发核糖体应激反应,抑制DNA、RNA和蛋白的合成,诱导细胞凋亡等作用,对肠道、免疫系统造成破坏,并且具有遗传毒性,对人和动物的身体健康具有严重影响,是人畜食品中检出率和超标率最高的一种真菌毒素。 |
MDL号 | MFCD09039270 |
危险品标志 | T - 有毒物品 Xn - 有害物品 F - 易燃物品 Xi - 刺激性物品 |
风险术语 | R25 - 吞食有毒。 R68/20/21/22 - R67 - 蒸汽可能引起困倦和眩晕。 R66 - 长期接触可能引起皮肤干裂。 R36 - 刺激眼睛。 R20/21/22 - 吸入、皮肤接触及吞食有害。 R11 - 高度易燃。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S16 - 远离火源。 S36/37 - 穿戴适当的防护服和手套。 S37/39 - 戴适当的手套和护目镜或面具。 |
危险品运输编号 | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | YD0167000 |
海关编号 | 29329990 |
Hazard Class | 6.1(a) |
Packing Group | I |
参考资料 展开查看 | 1. 珊珊,刘光芒,王建萍,林燕,白世平,张克英,吴彩梅.有氧条件下污染禾谷镰刀菌的玉米品质变化规律和呕吐毒素的积累动态变化规律[J].微生物学报,2020,60(08):1661-1671. 2. 闫珊珊,刘光芒,王建萍,林燕,白世平,张克英,吴彩梅.缺氧条件下受禾谷镰刀菌污染的玉米蛋白粉品质变化规律和呕吐毒素(DON)的积累规律研究[J].四川农业大学学报,2020,38(01):8-17. 3. He, Baoshan, and Xiaoze Dong. "Aptamer based voltammetric patulin assay based on the use of ZnO nanorods." Microchimica Acta 185.10 (2018): 1-8.https://doi.org/10.1007/s00604-018-3006-0 4. Baoshan He, Xiaohai Yan, A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone, Sensors and Actuators B: Chemical, Volume 290, 2019, Pages 477-483, ISSN 0925-4005, https://doi.org/10.1016/j 5. He, B., Yan, X. An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide. Microchim Acta 186, 383 (2019). https://doi.org/10.1 6. He, B., Yan, X. An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide. Microchim Acta 186, 383 (2019). https://doi.org/10.1 7. [IF=5.833] He Baoshan et al."Aptamer based voltammetric patulin assay based on the use of ZnO nanorods."Microchim Acta. 2018 Oct;185(10):1-8 8. [IF=7.46] Baoshan He et al."A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone."Sensor Actuat B-Chem. 2019 Jul;290:477 9. [IF=7.46] Long Wang et al."A DNAzyme-assisted triple-amplified electrochemical aptasensor for ultra-sensitive detection of T-2 toxin."Sensor Actuat B-Chem. 2021 Feb;328:129063 10. [IF=6.023] Yongsong Bai et al."Deoxynivalenol exposure induces liver damage in mice: Inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG."Food Chem Toxicol. 2021 Oct;156:112514 11. [IF=5.833] He Baoshan et al."An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide."Microchim Acta. 2019 Jun;186(6):1-10 12. [IF=5.279] Zongzhe He et al."Deoxynivalenol in Fusarium graminearum: Evaluation of Cyproconazole Stereoisomers In Vitro and In Planta."J Agr Food Chem. 2021;69(34):9735–9742 |
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