DEOXYNIVALENOL
DEOXYNIVALENOL
CAS: 51481-10-8
Molecular Formula: C15H20O6
DEOXYNIVALENOL - Names and Identifiers
DEOXYNIVALENOL - Physico-chemical Properties
| Molecular Formula | C15H20O6 |
| Molar Mass | 296.32 |
| Density | 1.48 |
| Melting Point | 151-153 C |
| Boling Point | 357.92°C (rough estimate) |
| Flash Point | -3 °C |
| Solubility | Soluble in methanol, chloroform, water (slightly), ethanol (9.8 - 10.2 mg/ml), and DMSO. |
| Appearance | Morphological solution (ethanol: 2-propanol 95:5) |
| pKa | 11.91±0.70(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.4359 (estimate) |
| MDL | MFCD09039270 |
| Physical and Chemical Properties | Chemical properties DON can combine with the peptide transferase activity center of the ribosomal 60s subunit to trigger ribosomal stress response, inhibit the synthesis of DNA, RNA and protein, induce apoptosis and other effects, and cause damage to the intestinal and immune systems. It is genotoxic and has a serious impact on the health of humans and animals. It is a mycotoxin with the highest detection rate and over-standard rate in human and animal foods. |
| Use | Uses Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Deoxynivalenol exhibits cytotoxic activity in vivo via the ribotoxic stress response. Deoxynivalenol induces p38-medi ated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-Wei B into the nucleus. |
DEOXYNIVALENOL - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R68/20/21/22 - R67 - Vapors may cause drowsiness and dizziness R66 - Repeated exposure may cause skin dryness or cracking R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | YD0167000 |
| HS Code | 29329990 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 i.p. in male, female mice (mg/kg): 70.0, 76.7 (Yoshizawa, Morooka) |
DEOXYNIVALENOL - Reference
| Reference Show more | 1. Shanshan, Liu Guangping, Wang Jianping, Lin Yan, Bai Shiping, Zhang Keying, Wu caime. Dynamic changes of quality and Vomit toxin accumulation of contaminated Fusarium graminearum maize under aerobic condition [J]. Journal of Microbiology, 2020,60(08):1661-1671. 2. Yan Shanshan, Liu guangguang, Wang Jianping, Lin Yan, Bai Shiping, Zhang Keying, Wu caime. Study on quality variation and accumulation of Vomit toxin (DON) in corn gluten meal contaminated by Fusarium graminearum under anoxic condition [J]. Journal of Sichuan Agricultural University, 2020,38(01):8-17. 3. He, Baoshan, and Xiaoze Dong. "Aptamer-based voltammetric patulin." Microchimica Acta 185.10 (2018): 1-8.https:// doi.org/10.1007/s00604-018-3006-0 4. Baoshan He, Xiaohai Yan, A "signal-on" voltammetric aptassor fabricated by hcPt @ AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone, Sensors and Actuators B: Chemical, Volume 290, 2019, Pages 477-483, ISSN 0925-4005, https://doi.org/10.1016/j 5. He, B ., Yan, X. An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide. Microchim Acta 186, 383 (2019). https://doi.org/10.1 6. He, B ., Yan X. An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide. Microchim Acta 186, 383 (2019). https://doi.org/10.1 7. [IF=5.833] He Baoshan et al."Aptamer based voltammetric patulin assay based on the use of ZnO nanorods."Microchim Acta. 2018 Oct;185(10):1-8 8. [IF=7.46] Baoshan He et al."A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone."Sensor Actuat B- Chem. 2019 Jul;290:477 9. [IF=7.46] Long Wang et al."A DNAzyme-assisted triple-amplified electrochemical aptasensor for ultra-sensitive detection of T-2 toxin."Sensor Actuat B- Chem. 2021 Feb;328:129063 10. [IF=6.023] Yongsong Bai et al."Deoxynivalenol exposure induces liver damage in mice: Inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG."Food Chem Toxicol. 2021 Oct;156:112514 11. [IF=5.833] He Baoshan et al."An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide."Microchim Acta. 2019 Jun;186(6):1-10 12. [IF=5.279] Zongzhe He et al."Deoxynivalenol in Fusarium graminearum: Evaluation of Cyproconazole Stereoisomers In Vitro and In Planta."J Agr Food Chem. 2021;69(34):9735-9742 |
DEOXYNIVALENOL - Uses and synthesis methods
Introduction
deoxynivalenol is mainly produced by Fusarium graminearum (F. graminearum) and Fusarium yellow (F. culmorum), etc., and its content is higher in wheat, barley, oat, corn and other grains. Cereal deoxynivalenol pollution is prone to occur globally. The main reason is that grains are infected by Fusarium graminearum and other fungi in the field, resulting in head blight and corn ear rot in wheat. Reproduction and production of deoxynivalenol under conditions such as temperature and humidity.
biological activity
Deoxynivalenol, a mycotoxin of the trichothecenes family, passes through the intestinal mucosa through the cell bypass at the tight junction. Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated protein (MRP) inhibitors.
category
Toxic substances
Toxicity classification
Highly toxic
Acute toxicity
oral-mouse LD50: 46 mg/kg; abdominal-mouse LD50: 43 mg/kg
Stimulus data
Skin-guinea pig 0.148 mg mild
flammability hazard characteristics
Flammable, hot and irritating smoke from the fire site
storage and transportation features
The warehouse is low temperature, ventilated and dry; stored separately from food ingredients
Fire extinguishing agent
Water, carbon dioxide, foam, sand
Last Update：2024-04-10 22:29:15
DEOXYNIVALENOL - Security information
| toxic substance data | 51481-10-8(Hazardous Substances Data) |
Last Update：2024-04-10 22:29:15
DEOXYNIVALENOL - Nature
| specific rotation | D25 6.35° (c = 0.07 in ethanol) |
| Merck | 13,10092 |
Last Update：2024-04-09 01:59:50
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Featured ProductsMultiple SpecificationsSpot supply
Product Name: Deoxynivalenol Visit Supplier Webpage Request for quotationCAS: 51481-10-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Deoxynivalenol Visit Supplier Webpage Request for quotationCAS: 51481-10-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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