中文名 | 蛋白A(重组) |
英文名 | Protein A |
别名 | A蛋白 蛋白A(重组) 1-磷酸鞘氨醇 D-苏式-鞘胺醇 D-赤型神经胺磷酸盐 D-苏式-鞘胺醇-1-磷酸 |
英文别名 | SPA 1-SPP Protein A SPHINGOSINE-1-PHOSPHATE D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE (E)-D-ERYTHRO-2-AMINO-1-(DIHYDROGENPHOSPHATE)-4-OCTADECENE-1,3-DIOL |
CAS | 26993-30-6 |
化学式 | C18H38NO5P |
分子量 | 379.47 |
密度 | 1.094±0.06 g/cm3(Predicted) |
熔点 | 179-189°C |
沸点 | 548.8±60.0 °C(Predicted) |
溶解度 | 甲醇: THF: 水 (6:3:1): >0.5mg/ml |
酸度系数 | 1.76±0.10(Predicted) |
存储条件 | -20°C |
稳定性 | 湿度,温度敏感; 吸湿性 |
敏感性 | Light Sensitive |
外观 | 蜡状固体 |
颜色 | yellow |
体外研究 | S1P (1 μM) induces a significant Ca 2+ releases in HEK293 cells under serum starvation conditions (1% FCS).In a functional Ca 2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca 2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca 2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells. In a functional Ca 2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC 50 values for gpr3 (EC 50 =29 nM), gpr6 (EC 50 =15 nM) and gpr12 (EC 50 =24 nM), rat gpr3 (EC 50 =68 nM),respectively in HEK293 cells. S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1and G qi5 , which allows for phospholipase C stimulation by G i proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2and S1P3receptors (EC 50 s = 8 and 11 nM, respectively). |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
RTECS | RG2260500 |
海关编号 | 29225090 |
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