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(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide

N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide

CAS: 136174-04-4

Molecular Formula: C20H25ClN2O2

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  4. (5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide

(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide - Names and Identifiers

Name N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide
Synonyms N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide
4-Dibenzofurancarboxamide, N-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-, (5as,9as)-
4-Dibenzofurancarboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2-chloro-5a,6,7,8,9,9a-hexahydro-, (5aS,9aS)- (9CI)
(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide
4-Dibenzofurancarboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-, (5as-(4(R*),5aalpha,9aalpha))-
CAS 136174-04-4

(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide - Physico-chemical Properties

Molecular FormulaC20H25ClN2O2
Molar Mass360.88
Density1.31±0.1 g/cm3(Predicted)
Boling Point462.6±45.0 °C(Predicted)
pKa13.83±0.20(Predicted)
Storage ConditionRoom Temprature
In vitro study RG 12915 is a potent and selective displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites (IC 50 value = 0.16 nM), whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites with IC 50 values less than 1 μM.
In vivo study RG 12915 has a lower ED 50 value (0.004 mg/kg) for attenuating cisplatin-induced emetic episodes in the ferret. RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species.

(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide - References

biological activity RG-12915 is a selective 5-HT3 antagonist with an IC50 value of 0.16 nM.
Last Update：2024-04-09 20:49:11
(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide Visit Supplier Webpage Request for quotation
CAS: 136174-04-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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(5As-(4(R*),5aalpha,9aalpha))-N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5A,6,7,8,9,9A-hexahydro-4-dibenzofurancarboxamide
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