(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE
BOC-3,4-DIMETHOXY-L-PHENYLALANINE
CAS: 127095-97-0
Molecular Formula: C16H23NO6
(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE - Names and Identifiers
| Name | BOC-3,4-DIMETHOXY-L-PHENYLALANINE |
| Synonyms | Boc-L-3,4-Dimethoxyphenylalanine BOC-3,4-DIMETHOXY-L-PHENYLALANINE (S)-BOC-3,4-DIMETHOXYPHENYLALANINE N-BOC-3,4-DIMETHOXY-L-PHENYLALANINE N-BOC-(S)-3,4-DIMETHOXYPHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE N-ALPHA-T-BUTOXYCARBONYL-L-(3,4-DIMETHOXY)PHENYLALANINE (S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-dimethoxyphenyl)propionic acid |
| CAS | 127095-97-0 |
| InChI | InChI=1/C16H23NO6/c1-16(2,3)23-15(20)17-11(14(18)19)8-10-6-7-12(21-4)13(9-10)22-5/h6-7,9,11H,8H2,1-5H3,(H,17,20)(H,18,19)/t11-/m0/s1 |
(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE - Physico-chemical Properties
| Molecular Formula | C16H23NO6 |
| Molar Mass | 325.36 |
| Density | 1.176±0.06 g/cm3(Predicted) |
| Boling Point | 482.7±45.0 °C(Predicted) |
| Flash Point | 245.732°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 2.98±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.518 |
| Physical and Chemical Properties | Storage Conditions: Store at 0 ℃ |
(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE - Risk and Safety
| Hazard Class | IRRITANT |
(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE - Introduction
Boc-L-3, 4-dimethoxyphenylalanine is an organic compound whose chemical formula is C_18H_25NO_6.
Nature:
-Appearance: Often a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and ethanol, and also soluble in water.
-Melting point: about 110-112°C.
Use:
Boc-L-3, 4-dimethoxyphenylalanine is a commonly used amino acid protecting group, which is commonly used in the synthesis of peptides and proteins. Its Boc protecting group can be easily removed after the reaction, making it widely used in solid phase synthesis and liquid phase synthesis.
Method:
Boc-L-3, the preparation of 4-dimethoxyphenylalanine is usually carried out by the following steps:
1. react L-3, 4-dimethoxyphenylalanine with di-tert-butyldimethylsilyl ether (TBDMS-Cl) in dimethylamide carbonate (DMF) to generate N-tert-butoxycarbodiimide of Boc-L-3, 4-dimethoxyphenylalanine.
2. Subsequently, it is reacted with an organic nucleophile, for example, it can be reacted with p-methoxybenzoyl chloride to produce the desired product.
Safety Information:
Boc-L-3, 4-dimethoxyphenylalanine is generally relatively safe under correct operation, but safe laboratory procedures should be followed in any chemical experiment. When in use, care should be taken to prevent inhalation, swallowing or skin contact. Also, avoid contact with oxidants or strong acids/bases and store them properly. In the event of an accident, appropriate first aid treatment should be carried out in a timely manner.
Nature:
-Appearance: Often a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and ethanol, and also soluble in water.
-Melting point: about 110-112°C.
Use:
Boc-L-3, 4-dimethoxyphenylalanine is a commonly used amino acid protecting group, which is commonly used in the synthesis of peptides and proteins. Its Boc protecting group can be easily removed after the reaction, making it widely used in solid phase synthesis and liquid phase synthesis.
Method:
Boc-L-3, the preparation of 4-dimethoxyphenylalanine is usually carried out by the following steps:
1. react L-3, 4-dimethoxyphenylalanine with di-tert-butyldimethylsilyl ether (TBDMS-Cl) in dimethylamide carbonate (DMF) to generate N-tert-butoxycarbodiimide of Boc-L-3, 4-dimethoxyphenylalanine.
2. Subsequently, it is reacted with an organic nucleophile, for example, it can be reacted with p-methoxybenzoyl chloride to produce the desired product.
Safety Information:
Boc-L-3, 4-dimethoxyphenylalanine is generally relatively safe under correct operation, but safe laboratory procedures should be followed in any chemical experiment. When in use, care should be taken to prevent inhalation, swallowing or skin contact. Also, avoid contact with oxidants or strong acids/bases and store them properly. In the event of an accident, appropriate first aid treatment should be carried out in a timely manner.
Last Update：2024-04-10 22:29:15
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CAS: 127095-97-0
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QQ: 3008007409
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CAS: 127095-97-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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