N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE

N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE - Names and Identifiers

Name	BOC-3,4-DIMETHOXY-L-PHENYLALANINE
Synonyms	Boc-L-3,4-Dimethoxyphenylalanine BOC-3,4-DIMETHOXY-L-PHENYLALANINE (S)-BOC-3,4-DIMETHOXYPHENYLALANINE N-BOC-3,4-DIMETHOXY-L-PHENYLALANINE N-BOC-(S)-3,4-DIMETHOXYPHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE N-ALPHA-T-BUTOXYCARBONYL-L-(3,4-DIMETHOXY)PHENYLALANINE (S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-dimethoxyphenyl)propionic acid
CAS	127095-97-0
InChI	InChI=1/C16H23NO6/c1-16(2,3)23-15(20)17-11(14(18)19)8-10-6-7-12(21-4)13(9-10)22-5/h6-7,9,11H,8H2,1-5H3,(H,17,20)(H,18,19)/t11-/m0/s1

N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE - Physico-chemical Properties

Molecular Formula	C16H23NO6
Molar Mass	325.36
Density	1.176±0.06 g/cm3(Predicted)
Boling Point	482.7±45.0 °C(Predicted)
Flash Point	245.732°C
Vapor Presure	0mmHg at 25°C
pKa	2.98±0.10(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.518
Physical and Chemical Properties	Storage Conditions: Store at 0 ℃

N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE - Risk and Safety

Hazard Class

IRRITANT

N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE - Introduction

Boc-L-3, 4-dimethoxyphenylalanine is an organic compound whose chemical formula is C_18H_25NO_6.

Nature:
-Appearance: Often a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and ethanol, and also soluble in water.
-Melting point: about 110-112°C.

Use:
Boc-L-3, 4-dimethoxyphenylalanine is a commonly used amino acid protecting group, which is commonly used in the synthesis of peptides and proteins. Its Boc protecting group can be easily removed after the reaction, making it widely used in solid phase synthesis and liquid phase synthesis.

Method:
Boc-L-3, the preparation of 4-dimethoxyphenylalanine is usually carried out by the following steps:
1. react L-3, 4-dimethoxyphenylalanine with di-tert-butyldimethylsilyl ether (TBDMS-Cl) in dimethylamide carbonate (DMF) to generate N-tert-butoxycarbodiimide of Boc-L-3, 4-dimethoxyphenylalanine.
2. Subsequently, it is reacted with an organic nucleophile, for example, it can be reacted with p-methoxybenzoyl chloride to produce the desired product.

Safety Information:
Boc-L-3, 4-dimethoxyphenylalanine is generally relatively safe under correct operation, but safe laboratory procedures should be followed in any chemical experiment. When in use, care should be taken to prevent inhalation, swallowing or skin contact. Also, avoid contact with oxidants or strong acids/bases and store them properly. In the event of an accident, appropriate first aid treatment should be carried out in a timely manner.

Last Update：2024-04-10 22:29:15