(methylamino)ethanoicacid
Sarcosine
CAS: 107-97-1
Molecular Formula: C3H7NO2
(methylamino)ethanoicacid - Names and Identifiers
| Name | Sarcosine |
| Synonyms | H-Sar-OH Sarcosine CH3NHCH2COOH Methylglycine N-Methylglycine N-Methylglycine) Methyl-glycocoll Glycine,N-methyl- Glycine, N-methyl- Methylaminoacetic acid (methylamino)ethanoicacid Acetic acid, (methylamino)- 2-(MethylaMino)acetic acid sodiuM Sarcosine,(Methylaminoacetic acid |
| CAS | 107-97-1 |
| EINECS | 203-538-6 |
| InChI | InChI=1/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) |
(methylamino)ethanoicacid - Physico-chemical Properties
| Molecular Formula | C3H7NO2 |
| Molar Mass | 89.09 |
| Density | 1.1948 (rough estimate) |
| Melting Point | 208-212°C (dec.)(lit.) |
| Boling Point | 165.17°C (rough estimate) |
| Flash Point | >100℃ |
| Water Solubility | 1480 g/L (20 ºC) |
| Solubility | Soluble in water, ethanol and dilute ethanol, insoluble in propylene glycol and grease |
| Vapor Presure | 0.184mmHg at 25°C |
| Appearance | Light brown powder with a slight pink color |
| Color | Colorless or white to yellow |
| Merck | 14,8373 |
| BRN | 1699442 |
| pKa | 2.21(at 25℃) |
| PH | 6.1 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Sensitive | Hygroscopic |
| Refractive Index | 1.4368 (estimate) |
| MDL | MFCD00004279 |
| Physical and Chemical Properties | Light brown powder with a slightly pink tint. There is spicy and astringent taste. As a commodity, there are also prepared after the water solution with sulfur dioxide anti-corrosion. The surface tension of the 0.1% solution was 3.58 (pH 7.0~3.82) or (ph). Heat resistance is strong, in PH 3~7 water solution heating, does not change or change. Strong foaming, can form a small, long-lasting foam. Soluble in water, ethanol and dilute ethanol, insoluble in propylene glycol and oil. The pH of the 1% aqueous solution is 4.5-5.5. |
| Use | Biochemical reagent, dye stabilizer, daily chemical, amino acid type surfactant, health care drug fatigue recovery agent |
(methylamino)ethanoicacid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 1 |
| RTECS | VQ2897000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 29224995 |
(methylamino)ethanoicacid - Reference
| Reference Show more | 1. Ji, Youan, et al. "Highly efficient separation of indole from model wash oil using tetraethyl ammonium amino acid ionic liquids." Separation and Purification Technology 258 (2021): 117997.https://doi.org/10.1016/j.seppur.2020.117997 2. [IF=4.105] Cong Wang et al."Heteronuclear MOF-based fluorescent sensor for the detection of tetracycline antibiotics."APPLIED ORGANOMETALLIC CHEMISTRY |
(methylamino)ethanoicacid - Introduction
Sarcosine (Sarcosine), non-coding amino acid. It is an intermediate in the natural metabolism of choline to glycine. Biological activity: Sarcosine is an intermediate and by-product in the synthesis and degradation of glycine. Sarcosine can be metabolized to produce glycine under the action of sarcosine dehydrogenase, and glycine is metabolized to produce sarcosine under the action of glycine transmethylase. Sarcosine is an amino acid derivative found in muscles and other body tissues. In the laboratory, it can be synthesized with chloroacetic acid and methylamine. Recently, sarcosine has been considered to be effective in reflecting the aggressiveness of prostate cancer, distinguishing the growth behavior of cancer cells, and can be detected in urine. The sarcosine content was also increased in aggressive prostate cancer cell lines compared to benign prostate epithelial cells. In addition to being an inhibitor of GlyT1 and a synergistic agonist of NMDAR, sarcosine is also an agonist of GlyR, but compared with glycine, sarcosine is weaker, so it is not a complete agonist. The cell viability of sarcosine-treated cells decreased significantly.
Last Update：2022-10-16 17:11:52
(methylamino)ethanoicacid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| non-protein amino acid | sarcosine (Creatine,N-methylglycine) is a kind of non-protein amino acid, as choline is naturally metabolized as glycine An intermediate in the process is very important to the human body. There are four sources: human body self-synthesis, chemical synthesis, plant extraction, and food source. The polymer with sarcosine as the repeating unit, that is, polysarcosine (pSar), has excellent biocompatibility, its degradation products are completely physiologically harmless, and polysarcosine has no charge, and has excellent hydrophilicity and reclusive effect. |
| toxicity | ADI O ~ 50 (tentative; FA0/wH0,2001). |
| use | 1. sarcosine can be used as a dye stabilizer for industrial products and as an amino acid surfactant for daily chemicals. it is also the main raw material for the production of creatine monohydrate, a fatigue recovery agent for health care drugs, participates in the synthesis of anti-enzyme agents and can be used as a biological reagent. 2. sarcosine can improve people's intelligence, especially for students' examinations, which require "temporary improvement of intelligence. 3. Sarcosine supplementation can increase muscle anaerobic strength and explosive power. Sarcosine exists in the form of creatine phosphate in the muscle. The human body mainly relies on ATP to provide energy during high-intensity exercise, but the ATP reserve in the human body is very small and requires continuous synthesis, and creatine phosphate can promote the synthesis of ATP. 4. Prevent damage caused by brain damage. 5. Sarcosine can effectively improve sports performance, strength, recovery time and pure lean muscles. Sarcosine exists in the form of creatine phosphate in the muscle. The human body mainly relies on ATP (adenosine triphosphate) to provide energy during high-intensity exercise, but the human body has very little ATP (adenosine triphosphate) reserves and requires continuous synthesis. Creatine phosphate can promote the synthesis of ATP (adenosine triphosphate). Biochemical research. Synthesis of anti-enzyme agents. Biochemical reagents, dye stabilizers, daily chemistry, amino acid surfactants, health care drugs fatigue recovery agents, etc. |
| production method | the bark (phloem) of soap tree (Quillaia saponaria) is extracted with hot water or aqueous ethanol, then precipitated by ether or acetone, and then recrystallized and refined. The main component is saponin (saponin, etc.). The tree is mainly wild in Chile, Bolivia and other places in South America, and also produced in China. |
Last Update：2024-04-09 20:13:35
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