,5-Dichloropyridine-4-carboxaldehyde
3,5-dichloro-4-formyl pyridine
CAS: 136590-83-5
Molecular Formula: C6H3Cl2NO
,5-Dichloropyridine-4-carboxaldehyde - Names and Identifiers
,5-Dichloropyridine-4-carboxaldehyde - Physico-chemical Properties
| Molecular Formula | C6H3Cl2NO |
| Molar Mass | 176 |
| Density | 1.488±0.06 g/cm3(Predicted) |
| Melting Point | 75-79 °C (lit.) |
| Boling Point | 242.4±35.0 °C(Predicted) |
| Flash Point | 100.4°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.0341mmHg at 25°C |
| Appearance | Solid |
| Color | White to Brown |
| pKa | -0.42±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.608 |
| MDL | MFCD04039921 |
| Physical and Chemical Properties | WGK Germany:3 |
,5-Dichloropyridine-4-carboxaldehyde - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
,5-Dichloropyridine-4-carboxaldehyde - Introduction
3,5-Dichloropyridine -4-carbaldehyde (3,5-Dichloro-4-formylpyriridine) is an organic compound with the chemical formula C- HCl-NO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3,5-dichloropyridine -4-carbaldehyde is a colorless to light yellow solid.
-Solubility: Its solubility in water is low, but it can be dissolved in organic solvents such as methanol, ethanol and dimethylformamide (DMF).
-Melting point: Its melting point is about 73-77°C.
-Smelly: It has a special smell.
Use:
-3,5-dichloropyridine -4-formaldehyde is an important organic synthesis intermediate, commonly used in the synthesis of drugs, dyes, photosensitive materials and pesticides and other compounds.
-It can also be used as a ligand in palladium-catalyzed nucleophilic substitution reactions.
Preparation Method:
- 3,5-dichloropyridine -4-carbaldehyde can be obtained by reacting 3,5-dichloropyridine with formaldehyde under alkaline conditions. The reaction is typically carried out in an alcoholic solution of formaldehyde with the addition of a base such as sodium hydroxide (NaOH) or sodium carbonate (Na₂ CO₂).
-After the reaction is completed, the produced 3,5-dichloropyridine-4-carbaldehyde can be separated and extracted by crystallization or other purification methods.
Safety Information:
-3,5-Dichloropyridine-4-carboxaldehyde is an irritating compound that may cause irritation to the eyes, skin and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves and goggles, to avoid direct contact with skin and eyes.
-During operation and storage, avoid contact with oxidants and strong acids to prevent dangerous reactions.
-Due to its toxicity and irritation, please operate in a well-ventilated place and avoid inhaling its vapor.
-When handling this compound, please follow the relevant safety practices and guidelines.
Nature:
-Appearance: 3,5-dichloropyridine -4-carbaldehyde is a colorless to light yellow solid.
-Solubility: Its solubility in water is low, but it can be dissolved in organic solvents such as methanol, ethanol and dimethylformamide (DMF).
-Melting point: Its melting point is about 73-77°C.
-Smelly: It has a special smell.
Use:
-3,5-dichloropyridine -4-formaldehyde is an important organic synthesis intermediate, commonly used in the synthesis of drugs, dyes, photosensitive materials and pesticides and other compounds.
-It can also be used as a ligand in palladium-catalyzed nucleophilic substitution reactions.
Preparation Method:
- 3,5-dichloropyridine -4-carbaldehyde can be obtained by reacting 3,5-dichloropyridine with formaldehyde under alkaline conditions. The reaction is typically carried out in an alcoholic solution of formaldehyde with the addition of a base such as sodium hydroxide (NaOH) or sodium carbonate (Na₂ CO₂).
-After the reaction is completed, the produced 3,5-dichloropyridine-4-carbaldehyde can be separated and extracted by crystallization or other purification methods.
Safety Information:
-3,5-Dichloropyridine-4-carboxaldehyde is an irritating compound that may cause irritation to the eyes, skin and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves and goggles, to avoid direct contact with skin and eyes.
-During operation and storage, avoid contact with oxidants and strong acids to prevent dangerous reactions.
-Due to its toxicity and irritation, please operate in a well-ventilated place and avoid inhaling its vapor.
-When handling this compound, please follow the relevant safety practices and guidelines.
Last Update：2024-04-09 21:04:16
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View History
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