1,3,4-Trihydroxybenzene
1,2,4-Trihydroxybenzene
CAS: 533-73-3
Molecular Formula: C6H6O3
1,3,4-Trihydroxybenzene - Names and Identifiers
| Name | 1,2,4-Trihydroxybenzene |
| Synonyms | OXYHYDROQUINONE 1,2,4-Benzentril 1,2,4-Benzenetriol 1,3,4-Benzenetriol 2,5-Dihydroxyphenol benzene-1,2,3-triol benzene-1,2,4-triol Hydroquinone, hydroxy- 1,3,4-Trihydroxybenzene 1,2,4-Trihydroxybenzene 1,2,4-TRIHYDROXYBENZENE 2-Hydroxy-1,4-hydroquinone |
| CAS | 533-73-3 |
| EINECS | 208-575-1 |
| InChI | InChI=1/C6H6O3/c7-4-2-1-3-5(8)6(4)9/h1-3,7-9H |
1,3,4-Trihydroxybenzene - Physico-chemical Properties
| Molecular Formula | C6H6O3 |
| Molar Mass | 126.11 |
| Density | 1.488g/cm3 |
| Melting Point | 140℃ |
| Boling Point | 309°C at 760 mmHg |
| Flash Point | 164.3°C |
| Water Solubility | freely soluble |
| Vapor Presure | 0.000361mmHg at 25°C |
| Appearance | Color Plates from Et2O |
| pKa | 9.58±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.676 |
| Physical and Chemical Properties | Chemical properties The leaf-like crystals are obtained from ether. Melting point 140.5 ℃. Soluble in water, ethanol, ether, ethyl acetate, almost insoluble in chloroform, carbon disulfide, benzene. |
| Use | 1,2, 4-benzenetriol is a metabolite of benzene. Intermediate in organic synthesis, absorbent for gas analysis. |
1,3,4-Trihydroxybenzene - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| RTECS | DC4200000 |
| TSCA | Yes |
| HS Code | 2907 29 00 |
| Toxicity | oms-hmn:lym 50 mmol/L CNREA8 45,2471,85 |
1,3,4-Trihydroxybenzene - Upstream Downstream Industry
| Raw Materials | 1,4-Benzoquinone 1,2,4-Triacetoxybenzene |
| Downstream Products | 2,4,5-TRIHYDROXYBENZALDEHYDE 2,4,5-TRIHYDROXYBENZOIC ACID |
1,3,4-Trihydroxybenzene - Security information
| Hazard Note | Irritant/Keep Cold/Air Sensitive |
Last Update：2024-04-10 22:29:15
1,3,4-Trihydroxybenzene - Nature
| sensitivity | Air Sensitive |
| Merck | 14,1073 |
| BRN | 2042863 |
| NIST chemical information | 1,2,4-Benzenetriol(533-73-3) |
| EPA chemical information | 1,2,4-Benzenetriol (533-73-3) |
Last Update：2024-04-09 21:04:16
1,3,4-Trihydroxybenzene - Uses and synthesis methods
production method
1,2, 4-phloroglucinol triacetate is prepared from p-benzoquinone and acetic anhydride, and then acts with hydrochloric acid to obtain the product. Preparation of 1.1,2,4-Phloroglucinol Triacetate Dry p-benzoquinone is added to the mixture of acetic anhydride and concentrated sulfuric acid in stages, the reaction temperature is 40-50 ℃, and the reaction is 1-3h. Add cold water to the reactants, filter the precipitated precipitate, wash with cold water, and recrystallize with alcohol to obtain 1,2, 4-phloroglucinol triacetate. Melting point 96.5-97 ℃. Preparation of 2.1,2,4-Phloroglucinol 5% hydrochloric acid and 1,2,4-phloroglucinol triacetate were stirred and heated to 90 ℃, hydrolyzed for 20min, and cooled. Neutralize with sodium carbonate and filter. The filtrate is extracted with ether, and the ether extract is heated to evaporate the ether to obtain 1,2, 4-phenylenetriester.
category
toxic substances
toxicity classification
High toxicity
acute toxicity
subcutaneous-mouse LD50; 122 mg/kg years; Abdominal cavity-mouse LDL0: 125 mg/kg
flammability hazard characteristics
Flammable; combustion produces stimulating smoke
storage and transportation features
Ventilated and dry at low temperature; stored separately from warehouse food ingredients
fire extinguishing agent
Dry powder, foam, sand, carbon dioxide, mist water
Last Update：2024-04-09 21:04:16
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Raw Materials for 1,3,4-Trihydroxybenzene
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