1,3,5-Estratriene-3,17beta-diol

1,3,5-Estratriene-3,17beta-diol - Names and Identifiers

Name	β-estradiol
Synonyms	Estradiol B-estradiol β-estradiol Beta-Estradiol 17beta-Estradiol 17beta-estradiol Dihydrofolliculin dihydrofolliculin BETA-ESTRADIOL-16,16,17-D3 17BETA-ESTRADIOL-16,16,17-D3 1,3,5-Estratriene-3,17beta-diol 1,3,5-estratriene-3,17beta-diol 3,17beta-Dihydroxy-1,3,5(10)-estratriene 3,17beta-dihydroxy-1,3,5(10)-estratriene (8alpha,9beta,13alpha,14beta,17alpha)-estra-1,3,5(10)-triene-3,17-diol
CAS	50-28-2
EINECS	200-023-8
InChI	InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1
InChIKey	VOXZDWNPVJITMN-ZBRFXRBCSA-N

1,3,5-Estratriene-3,17beta-diol - Physico-chemical Properties

Molecular Formula	C18H24O2
Molar Mass	272.39
Density	1.0708 (rough estimate)
Melting Point	178-179°C(lit.)
Boling Point	355.44°C (rough estimate)
Specific Rotation(α)	D25 +76 to +83° (dioxane)
Flash Point	2℃
Water Solubility	Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Solubility	Dissolve in dioxane, acetone, slightly soluble in ethanol, insoluble in water
Vapor Presure	9.82E-09mmHg at 25°C
Appearance	White crystalline powder
Color	White to off-white
Merck	14,3703
BRN	1914275
pKa	pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
Storage Condition	room temp
Stability	Stable. Incompatible with strong oxidizing agents.
Refractive Index	80.4 ° (C=1, Dioxane
MDL	MFCD00003693
Physical and Chemical Properties	Melting Point: 173°C

1,3,5-Estratriene-3,17beta-diol - Risk and Safety

Risk Codes	R60 - May impair fertility R61 - May cause harm to the unborn child R45 - May cause cancer R63 - Possible risk of harm to the unborn child R64 - May cause harm to breast-fed babies R40 - Limited evidence of a carcinogenic effect R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R48 - Danger of serious damage to health by prolonged exposure
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S36 - Wear suitable protective clothing. S20 - When using, do not eat or drink.
UN IDs	2811
WGK Germany	3
RTECS	KG2975000
FLUKA BRAND F CODES	8-10
HS Code	29372390
Hazard Class	6.1
Packing Group	III
Toxicity	LD50 subcutaneous in rat: > 300mg/kg

1,3,5-Estratriene-3,17beta-diol - Reference

Reference

1. Houlian Mei, Gang Liu. Effect of 17 β-estradiol on Cognitive Disorder in neonatal rats [J]. Chinese Journal of Clinical Pharmacology, 202036, no.14, 2093-2095, 2099 pages microscopic PKU CSCD CA 2020.
2. Taoli, Wang, Fei, Li, Yunjiang, et al. TUNEL method to detect the protective effect of self-made compound Pueraria tablets on the uterus of aged rats [J]. Journal of Practical Medicine 2018 35(4): 340-342.
3. Xu Wanfeng, Su Jie, Weng Luan, et al. Effect of Yunkang oral liquid on early-onset ovarian insufficiency in mice.
4. Zhou Xueyan, Chen Renguo, Wei Qunli, Zhang Bei, Li Zhiyong, Yin Jiale, Yin Xiaoming. Determination of estrone and estradiol in human serum by liquid chromatography-tandem mass spectrometry [J]. Journal of Clinical Laboratory, 2015,33(05):328-332.
5. Deng Yi, Ren Pengfei, Zhang Yanping. Effects of Angelica sinensis from different areas of Gansu province on female hormone and uterus in rats. CNKI;WanFang, 2013.
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9. Luxin, Guo Qiusheng, Shi Hongzhu, etc. Effects of exogenous methyltestosterone on the growth and gonadal development of natural overwintering Leech.
10. Sha haolei, Zhang Zhiyan, Xia Jingfen, et al. Detection and risk assessment of typical environmental estrogens in Dongqian Lake, Ningbo [J]. Sichuan environment, 2015, 34(06):10-14.
11. Shi Hongjia, Chen Panpan, Guo Qiaosheng, etc. A preliminary study on the changes of sex steroid hormones in the gonad development cycle of Leech [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 043(018):3639-3643.
12. Zhang Xuhui, little younger sister of Yang Jingjing et al. Determination of anti-aging components in oviductus ranae and its medicated rat serum by HPLC [J]. Journal of Guangdong Pharmaceutical University 2018 034(004):P.417-421.
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17. Yanan Shao, Zihan Pan, Chuan Rong, Yinghui Wang, Hongxiang Zhu, Yuanyuan Zhang, Kefu Yu, 17β-estradiol as precursors of Cl/Br-DBPs in the disinfection process of different water samples, Environmental Pollution, Volume 241, 2018, Pages 9-18, ISSN 0269-7491
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1,3,5-Estratriene-3,17beta-diol - Nature

Open Data Verified Data

This product is white or milky white crystalline powder; Odorless. Dissolved in dioxane, acetone, slightly soluble in ethanol, insoluble in water. The melting point was 175-180 °c. Specific rotation 75.~82.
estradiol is a natural estrogen secreted in the body mainly by mature ovarian follicles. The effect is similar to that of diethylstilbestrol. It can promote the development of sexual organs, and make the endometrial hyperplasia, shedding, produce periodic menstruation, can inhibit the anterior pituitary gland secretion of gonadotropin and prolactin, and against estrogen.

Last Update：2024-01-02 23:10:35

1,3,5-Estratriene-3,17beta-diol - Introduction

No smell. This product is dissolved in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.

Last Update：2022-10-16 17:25:32

1,3,5-Estratriene-3,17beta-diol - Use

Open Data Verified Data

estrogen. For functional uterine bleeding, primary amenorrhea, menopausal syndrome and prostate cancer.
if it is used for milk withdrawal, intramuscular injection, 4mg each time before breast expansion, once a day, for about 4 days.

Last Update：2022-01-01 11:14:18