10486-61-0
Iodothiophene
CAS: 10486-61-0
Molecular Formula: C4H3IS
10486-61-0 - Names and Identifiers
| Name | Iodothiophene |
| Synonyms | iodothiophene Iodothiophene 3-Iodothiophene 3-lodothiophene 3-Thienyl iodide Thien-3-yl iodide Thiophene, 3-iodo- 3-Iodothiophene, stabilized with copper |
| CAS | 10486-61-0 |
| EINECS | 234-009-8 |
| InChI | InChI=1/C4H3IS/c5-4-1-2-6-3-4/h1-3H |
10486-61-0 - Physico-chemical Properties
| Molecular Formula | C4H3IS |
| Molar Mass | 210.04 |
| Density | 2.066 g/mL at 25 °C (lit.) |
| Melting Point | -13.4 °C |
| Boling Point | 75 °C/14 mmHg (lit.) |
| Flash Point | 173°F |
| Vapor Presure | 0.594mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Yellow |
| BRN | 105451 |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive |
| Refractive Index | n20/D 1.657(lit.) |
10486-61-0 - Risk and Safety
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29349990 |
10486-61-0 - Reference Information
| Uses | 3-iodothiophene is an important organic synthesis intermediate. In the nucleophilic substitution reaction of halogenated aromatic hydrocarbons, 3-iodothiophene is used as the synthesis of thiophene derivatives The intermediate has the highest activity, and it is easier to carry out nucleophilic substitution reactions and coupling reactions to construct C- N bonds, C- P bonds, C- C bonds and C- O bonds, synthesis of various active derivatives containing thiophene rings. |
| preparation | 8.04g(0.049 t001)3-bromothiophene, 0.47g(2.5 mm01)CuI, 0.43g(4.9 ret001)N,N'-dimethylethylenediamine, 16.27g(0.098 m01)I(I and 20mL n-butanol were added into a 100mL reactor, heated in an oil bath, and reacted at 120 ℃ under magnetic stirring. The reaction was stopped after 8h of GC follow-up analysis. Cool to room temperature, filter, wash the filter cake twice with chloroform, and combine the organic phase. Chloroform was evaporated at normal pressure and then distilled under reduced pressure (8.00kPa). 8.08g of fraction at 110-120 ℃ was collected, and the crude product yield was 78.29%. GC analysis product 3-iodothiophene mass fraction is 98.50%. Qualitative analysis results of products (MS):m/z = 210 (m),83,39. |
Last Update：2024-04-10 22:29:15
