1198097-97-0
Mirin
CAS: 1198097-97-0
Molecular Formula: C10H8N2O2S
1198097-97-0 - Names and Identifiers
1198097-97-0 - Physico-chemical Properties
| Molecular Formula | C10H8N2O2S |
| Molar Mass | 220.25 |
| Density | 1.49±0.1 g/cm3(Predicted) |
| Boling Point | 441.6±55.0 °C(Predicted) |
| Solubility | DMSO: ≥ 31 mg/mL |
| pKa | 8.70±0.30(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Mirin inhibits DSB-induced ATM activation, ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2, and MRN-dependent autophosphorylation of ATM at the Ser1981 site. Mirin also inhibited the G2 checkpoint in TOSA4 cells as well as homology-dependent DNA repair in HEK293 cells. In cells with integrated HPV16 (SiHa), Mirin increased the sensitivity of HPV epismes to PA25, resulting in a 5-fold decrease in the IC50 of pa25. Pre-treatment of mirin also reduced the cellular activity of cisplatin-treated 293 cells and inhibited the expression of proliferating cell nuclear antigen. |
1198097-97-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.54 ml | 22.702 ml | 45.403 ml |
| 5 mM | 0.908 ml | 4.54 ml | 9.081 ml |
| 10 mM | 0.454 ml | 2.27 ml | 4.54 ml |
| 5 mM | 0.091 ml | 0.454 ml | 0.908 ml |
Last Update：2024-01-02 23:10:35
1198097-97-0 - Reference Information
| biological activity | Mirin is an effective inhibitor of Mre11-Rad50-Nbs1(MRN) complex and can inhibit Mre11-related exonuctase activity. Mirin can inhibit the activation of MRN-dependent ATM. |
| target | TargetValue MRN () ATM () |
| Target | Value |
| In vitro study | Mirin inhibited DSB-induced ATM activation, ATM-dependent phosphorylation of Nbs1 and Chk2 downstream targets, and MRN-dependent ATM autophosphorylation at Ser1981 sites. Mirin also inhibited G2 checkpoint in TOSA4 cells as well as homologous-dependent DNA repair in HEK293 cells. In cells integrated with HPV16 (SiHa), Mirin increased the sensitivity of HPV episomes to PA25, reducing the IC50 of PA25 by a factor of 5. Pretreatment of mirin also reduced the cell activity of cisplatin-treated 293 cells and inhibited the expression of proliferating cell nuclear antigen. |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: Mirin Visit Supplier Webpage Request for quotationCAS: 1198097-97-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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