(Z)-Mirin MedChemExpress (MCE)

Product Name	Mirin
Synonyms	Mirin CS-2593 (Z)-Mirin (Z)-2-Amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one (5Z)-2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-
CAS	1198097-97-0
EINECS
Chemical Formula	C10H8N2O2S
Molecular Weight	220.25
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	(Z)-Mirin (Z)-Mirin MedChemExpress (MCE) HY-19959 1198097-97-0 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions (Z)-Mirin (Z)-Mirin MedChemExpress (MCE) HY-19959 1198097-97-0 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. (Z)-Mirin is an MRN (Mre11-Rad50-Nbs1) inhibitor. (Z)-Mirin prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity. (Z)-Mirin inhibits Mre11-associated exonuclease activity. (Z)-Mirin increases apoptosis, triggers a G2/M checkpoint and strongly inhibits homology-directed repair (HDR). (Z)-Mirin (50, 100, 500 μM) inhibits ATM-dependent phosphorylation of Nbs1 and Chk2 and the MRN-dependent autophosphorylation of ATM at Ser1981 in response to DNA double-strand breaks (DSBs). (Z)-Mirin (100 μM) inhibits Mre11 nuclease activity[1]. (Z)-Mirin (10-100 μM 24 h) shows 50% cytotoxicity at 50 μM in HEK293 cells[1]. (Z)-Mirin (10-100 μM) induces a substantial G2 arrest at concentrations of 50 μM and 100 μM[1]. (Z)-Mirin (18 µM 48 h) increases apoptosis in PEO4 cells[2]. \| \| \| \| \| \| \| \| \| \| [1]. Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28 49(6):1097-107. [Content Brief] [2]. Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3 288(18):12840-51. [Content Brief] [3]. Garner KM, et al. Corrected structure of Mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2009 Mar 5(3):129-30. [Content Brief] [4]. Aude Dupré, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008 Feb 4(2):119-25. [Content Brief] [5]. Adel Alblihy, et al. Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. Int J Mol Sci. 2023 Jun 30 24(13):10966. [Content Brief]
Last Update	2025-04-01 14:45:47

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